Ectodysplasin a pathway contributes to human and murine skin repair.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_15714EFF1E73
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Ectodysplasin a pathway contributes to human and murine skin repair.
Périodique
Journal of Investigative Dermatology
Auteur⸱e⸱s
Garcin C.L., Huttner K.M., Kirby N., Schneider P., Hardman M.J.
ISSN
1523-1747 (Electronic)
ISSN-L
0022-202X
Statut éditorial
Publié
Date de publication
2016
Volume
136
Numéro
5
Pages
1022-1030
Langue
anglais
Résumé
The highly conserved ectodysplasin A (EDA)/EDA receptor signaling pathway is critical during development for the formation of skin appendages. Mutations in genes encoding components of the EDA pathway disrupt normal appendage development, leading to the human disorder hypohidrotic ectodermal dysplasia. Spontaneous mutations in the murine Eda (Tabby) phenocopy human X-linked hypohidrotic ectodermal dysplasia. Little is known about the role of EDA signaling in adult skin homeostasis or repair. Because wound healing largely mimics the morphogenic events that occur during development, we propose a role for EDA signaling in adult wound repair. Here we report a pronounced delay in healing in Tabby mice, demonstrating a functional role for EDA signaling in adult skin. Moreover, pharmacological activation of the EDA pathway in both Tabby and wild-type mice significantly accelerates healing, influencing multiple processes including re-epithelialization and granulation tissue matrix deposition. Finally, we show that the healing promoting effects of EDA receptor activation are conserved in human skin repair. Thus, targeted manipulation of the EDA/EDA receptor pathway has clear therapeutic potential for the future treatment of human pathological wound healing.
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/02/2016 17:33
Dernière modification de la notice
20/08/2019 12:44
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