Les interactions immuno-neuroendocriniennes et leurs implications cliniques. [Interactions between the immune and neuroendocrine systems: clinical implications]

Détails

ID Serval
serval:BIB_156689CD5475
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Les interactions immuno-neuroendocriniennes et leurs implications cliniques. [Interactions between the immune and neuroendocrine systems: clinical implications]
Périodique
Journal de la Societe de Biologie
Auteur(s)
Gaillard  R. C.
ISSN
1295-0661 (Print)
Statut éditorial
Publié
Date de publication
2003
Volume
197
Numéro
2
Pages
89-95
Notes
English Abstract
Journal Article
Review
Résumé
The endocrine and immune systems are interrelated via a bidirectional network in which hormones affect immune function and, in turn, immune responses are reflected in neuroendocrine changes. This bidirectional communication is possible because both systems share a common "chemical language" that results from a sharing of common ligands (hormones and cytokines) and their specific receptors. Cytokines are important partners in this crosstalk. They play a role in modulating the hypothalamo-pituitary-adrenal (HPA) axis responses at all three levels: the hypothalamus, the pituitary gland and the adrenals. Acute effects of cytokines are produced at the central nervous system level, particularly the hypothalamus, whereas pituitary and adrenal actions are slower and are probably involved during prolonged exposure to cytokines such as during chronic inflammation or infection. Several mechanisms have been proposed by which peripheral cytokines may gain access to the brain. They include an active transport through the blood-brain barrier, a passage at the circumventricular organ level, as well as a neuronal pathway through the vagal nerve. The immune-neuroendocrine interactions are involved in numerous physiological and pathophysiological conditions and the interactions with the HPA axis may represent a mechanism through which the immune system, by stimulating the production of glucocorticoids, avoids an overshoot of inflammatory response. They may also be involved in the state of hypogonadism, of hypothyroidism and growth inhibition which can occur during inflammatory and infectious diseases. The crosstalk between the immune and endocrine systems is important to homeostasis, since the interactions can produce various appropriate adaptative responses when homeostasis is threatened.
Mots-clé
Animals Brain/immunology/physiology/physiopathology Cell Communication Cytokines/immunology Hormones/physiology Humans Immune System/*physiology Inflammation/immunology/physiopathology Neurosecretory Systems/*immunology
Pubmed
Création de la notice
15/02/2008 17:58
Dernière modification de la notice
20/08/2019 13:44
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