FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_15652A41591D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1.
Périodique
Journal of Cell Biology
Auteur(s)
Norrmén C., Ivanov K.I., Cheng J., Zangger N., Delorenzi M., Jaquet M., Miura N., Puolakkainen P., Horsley V., Hu J., Augustin H.G., Ylä-Herttuala S., Alitalo K., Petrova T.V.
ISSN
1540-8140 (Electronic)
ISSN-L
0021-9525
Statut éditorial
Publié
Date de publication
2009
Volume
185
Numéro
3
Pages
439-457
Langue
anglais
Résumé
The mechanisms of blood vessel maturation into distinct parts of the blood vasculature such as arteries, veins, and capillaries have been the subject of intense investigation over recent years. In contrast, our knowledge of lymphatic vessel maturation is still fragmentary. In this study, we provide a molecular and morphological characterization of the major steps in the maturation of the primary lymphatic capillary plexus into collecting lymphatic vessels during development and show that forkhead transcription factor Foxc2 controls this process. We further identify transcription factor NFATc1 as a novel regulator of lymphatic development and describe a previously unsuspected link between NFATc1 and Foxc2 in the regulation of lymphatic maturation. We also provide a genome-wide map of FOXC2-binding sites in lymphatic endothelial cells, identify a novel consensus FOXC2 sequence, and show that NFATc1 physically interacts with FOXC2-binding enhancers. As damage to collecting vessels is a major cause of lymphatic dysfunction in humans, our results suggest that FOXC2 and NFATc1 are potential targets for therapeutic intervention.
Mots-clé
Animals, Basement Membrane/physiology, Blood Vessels/physiology, Capillaries/physiology, Forkhead Transcription Factors/deficiency, Forkhead Transcription Factors/genetics, Heart Valves/physiology, Lymphatic Vessels/pathology, Lymphatic Vessels/physiology, Mice, Mice, Knockout, NFATC Transcription Factors/physiology, Skin Physiological Phenomena
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/08/2011 10:47
Dernière modification de la notice
20/08/2019 13:44
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