Selective bystander proliferation of memory CD4+ and CD8+ T cells upon NK T or T cell activation.

Détails

ID Serval
serval:BIB_15106
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Selective bystander proliferation of memory CD4+ and CD8+ T cells upon NK T or T cell activation.
Périodique
Journal of Immunology
Auteur⸱e⸱s
Eberl G., Brawand P., MacDonald H.R.
ISSN
0022-1767
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
165
Numéro
8
Pages
4305-4311
Langue
anglais
Résumé
Ag-experienced or memory T cells have increased reactivity to recall Ag, and can be distinguished from naive T cells by altered expression of surface markers such as CD44. Memory T cells have a high turnover rate, and CD8(+) memory T cells proliferate upon viral infection, in the presence of IFN-alphabeta and/or IL-15. In this study, we extend these findings by showing that activated NKT cells and superantigen-activated T cells induce extensive bystander proliferation of both CD8(+) and CD4(+) memory T cells. Moreover, proliferation of memory T cells can be induced by an IFN-alphabeta-independent, but IFN-gamma- or IL-12-dependent pathway. In these conditions of bystander activation, proliferating memory (CD44(high)) T cells do not derive from activation of naive (CD44(low)) T cells, but rather from bona fide memory CD44(high) T cells. Together, these data demonstrate that distinct pathways can induce bystander proliferation of memory T cells.
Mots-clé
Animals, Antigens, CD44/biosynthesis, CD4-Positive T-Lymphocytes/cytology, CD4-Positive T-Lymphocytes/drug effects, CD8-Positive T-Lymphocytes/cytology, CD8-Positive T-Lymphocytes/drug effects, Cell Differentiation/drug effects, Cell Differentiation/immunology, Cell Division/drug effects, Cell Division/immunology, Epitopes, T-Lymphocyte/immunology, Female, Galactosylceramides/pharmacology, HLA-C Antigens/biosynthesis, HLA-C Antigens/genetics, Humans, Immunologic Memory/drug effects, Killer Cells, Natural/drug effects, Killer Cells, Natural/immunology, Lymphocyte Activation/drug effects, Mast-Cell Sarcoma, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Knockout, T-Lymphocyte Subsets/cytology, T-Lymphocyte Subsets/drug effects, Tumor Cells, Cultured/transplantation
Pubmed
Web of science
Création de la notice
19/11/2007 13:07
Dernière modification de la notice
20/08/2019 13:44
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