Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7.

Détails

ID Serval
serval:BIB_14D41A904394
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7.
Périodique
Social psychiatry and psychiatric epidemiology
Auteur⸱e⸱s
Krantz M.F., Hjorthøj C., Ellersgaard D., Hemager N., Christiani C., Spang K.S., Burton B.K., Gregersen M., Søndergaard A., Greve A., Ohland J., Mortensen P.B., Plessen K.J., Bliksted V., Jepsen JRM, Thorup AAE, Mors O., Nordentoft M.
ISSN
1433-9285 (Electronic)
ISSN-L
0933-7954
Statut éditorial
Publié
Date de publication
01/2023
Peer-reviewed
Oui
Volume
58
Numéro
1
Pages
113-140
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Knowledge about representativity of familial high-risk studies of schizophrenia and bipolar disorder is essential to generalize study conclusions. The Danish High Risk and Resilience Study (VIA 7), a population-based case-control familial high-risk study, creates a unique opportunity for combining assessment and register data to examine cohort representativity.
Through national registers, we identified the population of 11,959 children of parents with schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and controls from which the 522 children participating in The VIA 7 Study (202 FHR-SZ, 120 FHR-BP and 200 controls) were selected. Socio-economic and health data were obtained to compare high-risk groups and controls, and participants versus non-participants. Selection bias impact on results was analyzed through inverse probability weights.
In the total sample of 11,959 children, FHR-SZ and FHR-BP children had more socio-economic and health disadvantages than controls (p < 0.001 for most). VIA 7 non-participants had a poorer function, e.g. more paternal somatic and mental illness (p = 0.02 and p = 0.04 for FHR-SZ), notifications of concern (FHR-BP and PBC p < 0.001), placements out of home (p = 0.03 for FHR-SZ), and lower level of education (p ≤ 0.01 for maternal FHR-SZ and FHR-BP, p = 0.001 for paternal FHR-BP). Inverse probability weighted analyses of results generated from the VIA Study showed minor changes in study findings after adjustment for the found selection bias.
Familial high-risk families have multiple socio-economic and health disadvantages. In The VIA 7 Study, although comparable regarding mental illness severity after their child's birth, socioeconomic and health disadvantages are more profound amongst non-participants than amongst participants.
Mots-clé
Male, Humans, Child, Bipolar Disorder/epidemiology, Bipolar Disorder/genetics, Schizophrenia/epidemiology, Cohort Studies, Selection Bias, Denmark/epidemiology, Familial high-risk, Generalizability, Representativity, Severe parental mental illness, Socio-economy
Pubmed
Web of science
Création de la notice
20/09/2022 13:06
Dernière modification de la notice
02/02/2023 7:52
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