Psychiatric comorbidity and additional abuse of drugs in maintenance treatment with l- and d,l-methadone.

Détails

ID Serval
serval:BIB_14D1FF1E78F1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Psychiatric comorbidity and additional abuse of drugs in maintenance treatment with l- and d,l-methadone.
Périodique
World Journal of Biological Psychiatry
Auteur(s)
Wedekind D., Jacobs S., Karg I., Luedecke C., Schneider U., Cimander K., Baumann P., Ruether E., Poser W., Havemann-Reinecke U.
ISSN
1814-1412[electronic], 1562-2975[linking]
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
9
Pages
1-10
Langue
anglais
Résumé
Sixty d,l- or l-methadone treated patients in maintenance therapy were interviewed for additional drug abuse and psychiatric comorbidity; 51.7% of the entire population had a comorbid Axis-I disorder, with a higher prevalence in females (P=0.05). Comorbid patients tended to have higher abuse of benzodiazepines, alcohol, cannabis, and cocaine, but not of heroin. They had received a significantly lower d,l- (P<0.05) and l-methadone dose than non-comorbid subjects. The duration of maintenance treatment showed an inverse relationship to frequency of additional heroin intake (P<0.01). Patients with additional heroin intake over the past 30 days had been treated with a significantly lower l-methadone dosage (P<0.05) than patients without. Axis-I comorbidity appears to be decreased when relatively higher dosages of d,l- (and l-methadone) are administered; comorbid individuals, however, were on significantly lower dosages. Finally, l-, but not d,l-methadone seems to be more effective in reducing additional heroin abuse.
Pubmed
Création de la notice
21/10/2008 15:07
Dernière modification de la notice
20/08/2019 13:43
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