Interictal cerebral metabolism and epilepsy in cavernous angiomas

Détails

ID Serval
serval:BIB_148E2D1D3584
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Interictal cerebral metabolism and epilepsy in cavernous angiomas
Périodique
Brain
Auteur⸱e⸱s
Ryvlin P., Mauguiere F., Sindou M., Froment J. C., Cinotti L.
ISSN
0006-8950 (Print)
ISSN-L
0006-8950
Statut éditorial
Publié
Date de publication
06/1995
Volume
118 ( Pt 3)
Pages
677-87
Langue
anglais
Notes
Ryvlin, P
Mauguiere, F
Sindou, M
Froment, J C
Cinotti, L
eng
England
Brain. 1995 Jun;118 ( Pt 3):677-87.
Résumé
We studied glucose metabolism in brain tissue surrounding cavernous angioma in 22 patients, using PET, and evaluated its relation to the size, site and epileptogenic nature of the vascular malformation, as well as to the post-surgical seizure outcome. Preoperatively, 18 patients suffered recurrent seizures, the origin of which could be clearly related to the vascular malformation in 14. Brain metabolism surrounding cavernous angiomas was normal in 18 patients (82%), and significantly decreased in four (18%). In these four patients, but in none of the 18 other cases, the vascular malformation disrupted connections between paralimbic areas and the adjacent temporal neocortex where hypometabolism was most pronounced. The latter did not correlate with the size nor with the epileptogenic nature of the cavernomas. Sixteen epileptic patients underwent surgical removal of their cavernoma, without resection of the surrounding cortex. At 1-year postoperatively, seizures have relapsed in seven patients (44%), including those four whose epilepsy could not be clearly related to the vascular malformation. Conversely, the four patients with perilesional hypometabolism on preoperative PET were seizure free postoperatively. Hypometabolism in brain tissue surrounding cavernomas is a rare finding which seems more likely to reflect deafferentation than the epileptogenic process itself.
Mots-clé
Adolescent, Adult, Brain/diagnostic imaging/*metabolism, Brain Neoplasms/complications/diagnostic imaging/*metabolism, Cerebral Arteries/abnormalities, Cerebral Veins/abnormalities, Epilepsy/diagnostic imaging/etiology/*metabolism/surgery, Female, Glucose/*metabolism, Hemangioma, Cavernous/complications/diagnostic imaging/*metabolism, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Prospective Studies, Recurrence, Tomography, Emission-Computed, Treatment Outcome
Pubmed
Création de la notice
29/11/2018 12:37
Dernière modification de la notice
20/08/2019 12:43
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