Control of the terminal step of intracellular membrane fusion by protein phosphatase 1.

Détails

ID Serval
serval:BIB_14736F40FB0C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Control of the terminal step of intracellular membrane fusion by protein phosphatase 1.
Périodique
Science
Auteur(s)
Peters C., Andrews P.D., Stark M.J., Cesaro-Tadic S., Glatz A., Podtelejnikov A., Mann M., Mayer A.
ISSN
0036-8075 (Print)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
1999
Peer-reviewed
Oui
Volume
285
Numéro
5430
Pages
1084-1087
Langue
anglais
Résumé
Intracellular membrane fusion is crucial for the biogenesis and maintenance of cellular compartments, for vesicular traffic between them, and for exo- and endocytosis. Parts of the molecular machinery underlying this process have been identified, but most of these components operate in mutual recognition of the membranes. Here it is shown that protein phosphatase 1 (PP1) is essential for bilayer mixing, the last step of membrane fusion. PP1 was also identified in a complex that contained calmodulin, the second known factor implicated in the regulation of bilayer mixing. The PP1-calmodulin complex was required at multiple sites of intracellular trafficking; hence, PP1 may be a general factor controlling membrane bilayer mixing.
Mots-clé
Biological Transport, Calcium/metabolism, Calmodulin/analysis, Calmodulin/metabolism, Carboxypeptidases/metabolism, Cathepsin A, Cell Membrane/metabolism, Endocytosis, Endoplasmic Reticulum/metabolism, Enzyme Inhibitors/pharmacology, Fluorescent Dyes, Golgi Apparatus/metabolism, Intracellular Membranes/metabolism, Membrane Fusion, Microcystins, Mutation, Peptides, Cyclic/pharmacology, Phosphoprotein Phosphatases/antagonists & inhibitors, Phosphoprotein Phosphatases/genetics, Protein Phosphatase 1, Pyridinium Compounds, Quaternary Ammonium Compounds, Saccharomyces cerevisiae/genetics, Saccharomyces cerevisiae/metabolism, Temperature, Vacuoles/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 15:06
Dernière modification de la notice
20/08/2019 12:43
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