Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors.

Détails

ID Serval
serval:BIB_146FEE3D7894
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors.
Périodique
Blood
Auteur(s)
Duda D.G., Cohen K.S., Kozin S.V., Perentes J.Y., Fukumura D., Scadden D.T., Jain R.K.
ISSN
0006-4971 (Print)
ISSN-L
0006-4971
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
107
Numéro
7
Pages
2774-2776
Langue
anglais
Résumé
Recent studies have demonstrated that the cellular contribution of the bone marrow to tumor neovascularization is highly complex. In this context, the extent to which bone marrow-derived cells incorporate as bona fide endothelial (nonhematopoietic) cells into perfused tumor vessels, or any new vessels formed postnatally (vasculogenesis), is unclear. To this end, we developed models to characterize local vessel-derived and bone marrow-derived endothelial cells (BMD-ECs). Then, we characterized the BMD-ECs based on a set of endothelial markers and morphology. Finally, we quantified their contribution to perfused blood vessels in tumors using transplanted as well as spontaneous primary and metastatic tumor models. We demonstrate that BMD-ECs incorporate in perfused tumor vessels, and that this contribution varies with organ site and mouse strain.
Mots-clé
Adenocarcinoma/blood, Biomarkers/analysis, Blood Vessels/physiopathology, Bone Marrow Cells/cytology, Breast Neoplasms/blood, Breast Neoplasms/pathology, Endothelium, Vascular/physiology, Female, Humans, Lung Neoplasms/blood, Melanoma/blood, Neoplasm Metastasis, Neoplasms/blood
Pubmed
Open Access
Oui
Création de la notice
01/07/2016 10:34
Dernière modification de la notice
20/08/2019 12:43
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