Anti-Apolipoprotein A-1 IgG Predict All-Cause Mortality and Are Associated with Fc Receptor-Like 3 Polymorphisms.

Détails

Ressource 1Télécharger: BIB_1439FD0AECBB.pdf (562.30 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_1439FD0AECBB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Anti-Apolipoprotein A-1 IgG Predict All-Cause Mortality and Are Associated with Fc Receptor-Like 3 Polymorphisms.
Périodique
Frontiers in immunology
Auteur(s)
Antiochos P., Marques-Vidal P., Virzi J., Pagano S., Satta N., Hartley O., Montecucco F., Mach F., Kutalik Z., Waeber G., Vollenweider P., Vuilleumier N.
ISSN-L
1664-3224
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
8
Pages
437
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Autoantibodies against apolipoprotein A-1 (anti-apoA-1 IgG) have emerged as an independent biomarker for cardiovascular disease and mortality. However, their association with all-cause mortality in the community, as well as their genetic determinants, have not been studied.
To determine whether anti-apoA-1 IgG: (a) predict all-cause mortality in the general population and (b) are associated with single-nucleotide polymorphisms (SNPs) in a genome-wide association study (GWAS).
Clinical, biological, and genetic data were obtained from the population-based, prospective CoLaus study, including 5,220 participants (mean age 52.6 years, 47.3% men) followed over a median duration of 5.6 years. The primary study outcome was all-cause mortality.
After multivariate adjustment, anti-apoA-1 IgG positivity independently predicted all-cause mortality: hazard ratio (HR) = 1.54, 95% confidence interval (95% CI): 1.11-2.13, P = 0.01. A dose-effect relationship was also observed, each SD of logarithmically transformed anti-apoA-1 IgG being associated with a 15% increase in mortality risk: HR = 1.15, 95% CI: 1.02-1.28, P = 0.028. The GWAS yielded nine SNPs belonging to the Fc receptor-like 3 (FCRL3) gene, which were significantly associated with anti-apoA-1 IgG levels, with the lead SNP (rs6427397, P = 1.54 × 10(-9)) explaining 0.67% of anti-apoA-1 IgG level variation.
Anti-apoA-1 IgG levels (a) independently predict all-cause mortality in the general population and (b) are linked to FCRL3, a susceptibility gene for numerous autoimmune diseases. Our findings indicate that preclinical autoimmunity to anti-apoA-1 IgG may represent a novel mortality risk factor.

Pubmed
Web of science
Open Access
Oui
Création de la notice
09/05/2017 17:23
Dernière modification de la notice
20/08/2019 12:42
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