Pulmonary haemorrhage as a predominant cause of death in leptospirosis in Seychelles.

Détails

Ressource 1Télécharger: serval:BIB_14343.P001 (1391.13 [Ko])
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
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ID Serval
serval:BIB_14343
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Pulmonary haemorrhage as a predominant cause of death in leptospirosis in Seychelles.
Périodique
Transactions of the Royal Society of Tropical Medicine and Hygiene
Auteur(s)
Yersin C., Bovet P., Mérien F., Clément J., Laille M., Van Ranst M., Perolat P.
ISSN
0035-9203
Statut éditorial
Publié
Date de publication
2000
Volume
94
Numéro
1
Pages
71-76
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
We examined the cause of death during a 12-month period (1995/96) in all consecutive patients admitted to hospital with leptospiral infection in Seychelles (Indian Ocean), where the disease is endemic. Leptospirosis was diagnosed by use of the microscopic agglutination test and a specific polymerase chain reaction assay on serum samples. Seventy-five cases were diagnosed and 6 patients died, a case fatality of 8%. All 6 patients died within 9 days of onset of symptoms and within 2 days of admission for 5 of them (5 days for the 6th). On autopsy, diffuse bilateral pulmonary haemorrhage (PH) was found in all fatalities. Renal, cardiac, digestive and cerebral haemorrhages were also found in 5, 3, 3 and 1 case(s), respectively. Incidentally, haemoptysis and lung infiltrate on chest radiographs, which suggest PH, were found in 8 of the 69 non-fatal cases. Dengue and hantavirus infections were ruled out. In conclusion, PH appeared to be a main cause of death in leptospirosis in this population, although haemorrhage in other organs may also have contributed to fatal outcomes. This cause of death contrasts with the findings generally reported in endemic settings.
Mots-clé
Adult, Cause of Death, Hemorrhage/microbiology, Hemorrhage/mortality, Humans, Incidence, Leptospirosis/mortality, Lung Diseases/microbiology, Lung Diseases/mortality, Male, Prospective Studies, Seychelles/epidemiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/11/2007 13:06
Dernière modification de la notice
01/10/2019 7:16
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