Sympathetic nerve activity in conscious renal hypertensive rats treated with an angiotensin converting enzyme inhibitor or an angiotensin II antagonist.

Détails

ID Serval
serval:BIB_13FC58C992F7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sympathetic nerve activity in conscious renal hypertensive rats treated with an angiotensin converting enzyme inhibitor or an angiotensin II antagonist.
Périodique
Journal of Hypertension
Auteur⸱e⸱s
Niederberger M., Aubert J.F., Nussberger J., Brunner H.R., Waeber B.
ISSN
0263-6352
Statut éditorial
Publié
Date de publication
1995
Peer-reviewed
Oui
Volume
13
Numéro
4
Pages
439-445
Langue
anglais
Notes
Journal Article --- Old month value: Apr
Résumé
OBJECTIVE: To assess in conscious two-kidney, one clip renal hypertensive rats whether angiotensin converting enzyme (ACE) inhibition with lisinopril, angiotensin II receptor blockade with losartan or vasodilation with sodium nitroprusside have similar effects on intra-arterial mean blood pressure, heart rate and splanchnic nerve activity. RESULTS: A bolus dose of lisinopril or losartan (both 10 mg/kg, intravenously) induced within 2 h an equal reduction in mean blood pressure, whereas sodium nitroprusside infused during the same period (at 10 micrograms/min) lowered mean blood pressure, but less strongly. The heart rate was accelerated significantly more during sodium nitroprusside infusion than during lisinopril or losartan treatment. Splanchnic nerve activity increased significantly only in those rats given sodium nitroprusside. No change in the parameters studied was observed in vehicle-treated rats. The doses of lisinopril and losartan were repeated after 12 and 24 h. Before administration of the last dose, the mean blood pressure was still low. Administration of lisinopril or losartan again 24 h after the initial dose had no further effect on the mean blood pressure, heart rate or splanchnic nerve activity. CONCLUSION: These results obtained in rats with a renin-dependent form of hypertension show that blockade of the renin-angiotensin system for 24 h produces an equivalent blood pressure reduction irrespective of whether it is due to ACE inhibition or angiotensin II antagonism. The results also indicate that there is less reflex activation of sympathetic nerve activity when blood pressure is lowered with a blocker of the renin-angiotensin system rather than with a direct vasodilator such as sodium nitroprusside.
Mots-clé
Angiotensin I, Angiotensin II, Animals, Biphenyl Compounds, Blood Pressure, Disease Models, Animal, Heart Rate, Hypertension, Renal, Imidazoles, Lisinopril, Losartan, Male, Nitroprusside, Rats, Rats, Wistar, Receptors, Angiotensin, Renin-Angiotensin System, Splanchnic Nerves, Sympathetic Nervous System, Tetrazoles
Pubmed
Web of science
Création de la notice
05/03/2008 17:40
Dernière modification de la notice
20/08/2019 13:42
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