Effects of unilateral motor cortex lesion on ipsilesional hand's reach and grasp performance in monkeys: relationship with recovery in the contralesional hand.

Détails

ID Serval
serval:BIB_13E48093B80F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of unilateral motor cortex lesion on ipsilesional hand's reach and grasp performance in monkeys: relationship with recovery in the contralesional hand.
Périodique
Journal of Neurophysiology
Auteur(s)
Kaeser Melanie, Wyss Alexander F., Bashir Shahid, Hamadjida Adjia, Liu Yu, Bloch Jocelyne, Brunet Jean-Francois, Belhaj-Saif Abderaouf, Rouiller Eric M.
ISSN
1522-1598[electronic], 0022-3077[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
103
Numéro
3
Pages
1630-1645
Langue
anglais
Résumé
Manual dexterity, a prerogative of primates, is under the control of the corticospinal (CS) tract. Because 90-95% of CS axons decussate, it is assumed that this control is exerted essentially on the contralateral hand. Consistently, unilateral lesion of the hand representation in the motor cortex is followed by a complete loss of dexterity of the contralesional hand. During the months following lesion, spontaneous recovery of manual dexterity takes place to a highly variable extent across subjects, although largely incomplete. In the present study, we tested the hypothesis that after a significant postlesion period, manual performance in the ipsilesional hand is correlated with the extent of functional recovery in the contralesional hand. To this aim, ten adult macaque monkeys were subjected to permanent unilateral motor cortex lesion. Monkeys' manual performance was assessed for each hand during several months postlesion, using our standard behavioral test (modified Brinkman board task) that provides a quantitative measure of reach and grasp ability. The ipsilesional hand's performance was found to be significantly enhanced over the long term (100-300 days postlesion) in six of ten monkeys, with the six exhibiting the best, though incomplete, recovery of the contralesional hand. There was a statistically significant correlation (r = 0.932; P < 0.001) between performance in the ipsilesional hand after significant postlesion period and the extent of recovery of the contralesional hand. This observation is interpreted in terms of different possible mechanisms of recovery, dependent on the recruitment of motor areas in the lesioned and/or intact hemispheres.
Mots-clé
Induced Movement Therapy, A Antibody Treatment, Positron-Emission-Tomography, Randomized Clinical-Trial, Upper Extremity Function, Chronic Stroke Patients, Corticospinal Tract, Premotor Cortex, Nonhuman-Primates, Shoulder Muscles
Pubmed
Web of science
Création de la notice
06/04/2010 15:26
Dernière modification de la notice
20/08/2019 12:42
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