Failure of vancomycin continuous infusion against experimental endocarditis due to vancomycin-intermediate Staphylococcus aureus.
Détails
ID Serval
serval:BIB_13C7B4B119E1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Failure of vancomycin continuous infusion against experimental endocarditis due to vancomycin-intermediate Staphylococcus aureus.
Périodique
Antimicrobial Agents and Chemotherapy
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
55
Numéro
1
Pages
385-387
Langue
anglais
Résumé
Continuous infusion of vancomycin was evaluated against experimental endocarditis due to heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) and VISA. Animals were infected with hVISA PC1 (vancomycin MIC, 2 mg/liter) or VISA PC3 (vancomycin MIC, 8 mg/liter) and treated for 5 days with constant serum levels of 20 or 40 mg/liter. Vancomycin continuous infusion was unsuccessful, as 20 mg/liter was barely active against PC1 (6 of 13 sterile vegetations) and 40 mg/liter failed against PC3 (2 of 9 sterile vegetations).
Mots-clé
Animals, Anti-Bacterial Agents/pharmacology, Anti-Bacterial Agents/therapeutic use, Endocarditis/drug therapy, Endocarditis/microbiology, Rats, Staphylococcus aureus/drug effects, Staphylococcus aureus/pathogenicity, Vancomycin/pharmacology, Vancomycin/therapeutic use, Vancomycin Resistance
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/01/2011 15:30
Dernière modification de la notice
20/08/2019 13:42