Phenolic glycolipid-1 from M. leprae inhibits oxygen free radical production by human mononuclear cells.
Détails
ID Serval
serval:BIB_13800CCBCF9E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Phenolic glycolipid-1 from M. leprae inhibits oxygen free radical production by human mononuclear cells.
Périodique
Research in Immunology
ISSN
0923-2494 (Print)
ISSN-L
0923-2494
Statut éditorial
Publié
Date de publication
1989
Volume
140
Numéro
9
Pages
847-855
Langue
anglais
Résumé
We studied the effect of PGL1, a phenolic glycolipid unique to Mycobacterium leprae, on the activation of the phagocyte oxidative respiratory burst, by measuring the chemiluminescence (CL) generated by normal mononuclear cells. PGL1 induced a decrease in oxygen free radical production stimulated by mycobacteria (M. leprae, BCG and M. kansasii) or by phorbol myristate acetate, but did not prevent the binding or ingestion of fluorescein-conjugated mycobacteria. In contrast, mycoside A from M. kansasii, a structurally related compound, did not alter the CL response. In addition, treatment of M. leprae with anti-PGL1 antibodies failed to restore the response to this microorganism. PGL1 could act as an oxygen species scavenger and protect M. leprae from killing by toxic oxygen metabolites.
Mots-clé
Adult, Antibodies, Bacterial/pharmacology, Antigens, Bacterial, Free Radicals, Glycolipids/immunology, Glycolipids/pharmacology, Humans, Leukocytes, Mononuclear/drug effects, Leukocytes, Mononuclear/immunology, Luminescent Measurements, Mycobacterium/immunology, Mycobacterium bovis/immunology, Mycobacterium leprae/immunology, Oxygen/blood, Phagocytosis/drug effects, Tetradecanoylphorbol Acetate/pharmacology
Pubmed
Web of science
Création de la notice
28/01/2008 12:06
Dernière modification de la notice
20/08/2019 13:42