Phenolic glycolipid-1 from M. leprae inhibits oxygen free radical production by human mononuclear cells.

Détails

ID Serval
serval:BIB_13800CCBCF9E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Phenolic glycolipid-1 from M. leprae inhibits oxygen free radical production by human mononuclear cells.
Périodique
Research in Immunology
Auteur⸱e⸱s
Launois P., Blum L., Dieye A., Millan J., Sarthou J.L., Bach M.A.
ISSN
0923-2494 (Print)
ISSN-L
0923-2494
Statut éditorial
Publié
Date de publication
1989
Volume
140
Numéro
9
Pages
847-855
Langue
anglais
Résumé
We studied the effect of PGL1, a phenolic glycolipid unique to Mycobacterium leprae, on the activation of the phagocyte oxidative respiratory burst, by measuring the chemiluminescence (CL) generated by normal mononuclear cells. PGL1 induced a decrease in oxygen free radical production stimulated by mycobacteria (M. leprae, BCG and M. kansasii) or by phorbol myristate acetate, but did not prevent the binding or ingestion of fluorescein-conjugated mycobacteria. In contrast, mycoside A from M. kansasii, a structurally related compound, did not alter the CL response. In addition, treatment of M. leprae with anti-PGL1 antibodies failed to restore the response to this microorganism. PGL1 could act as an oxygen species scavenger and protect M. leprae from killing by toxic oxygen metabolites.
Mots-clé
Adult, Antibodies, Bacterial/pharmacology, Antigens, Bacterial, Free Radicals, Glycolipids/immunology, Glycolipids/pharmacology, Humans, Leukocytes, Mononuclear/drug effects, Leukocytes, Mononuclear/immunology, Luminescent Measurements, Mycobacterium/immunology, Mycobacterium bovis/immunology, Mycobacterium leprae/immunology, Oxygen/blood, Phagocytosis/drug effects, Tetradecanoylphorbol Acetate/pharmacology
Pubmed
Web of science
Création de la notice
28/01/2008 12:06
Dernière modification de la notice
20/08/2019 13:42
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