Region-specific effect of testosterone on oxytocin receptor binding in the brain of the aged rat

Détails

ID Serval
serval:BIB_137BA1BC20DB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Region-specific effect of testosterone on oxytocin receptor binding in the brain of the aged rat
Périodique
Brain Research
Auteur(s)
Arsenijevic  Y., Tribollet  E.
ISSN
0006-8993 (Print)
Statut éditorial
Publié
Date de publication
02/1998
Volume
785
Numéro
1
Pages
167-70
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb 23
Résumé
We reported previously a significant reduction of oxytocin (OT) receptor binding in the brain of 20-month old rats relative to 3-month old ones. The present study shows that testosterone treatment of aging rats restores normal adult levels of OT receptor binding in the olfactory tubercle and in the hypothalamic ventromedial nucleus, but not in the caudate-putamen. These data indicate that the reduced plasma testosterone found in 20-month old rats is responsible for the loss of OT receptors in the olfactory tubercle and hypothalamic ventromedial nucleus, whereas other aging-related mechanisms may account for the decrease of OT receptor binding in the caudate-putamen.
Mots-clé
Aging/*metabolism Animals Autoradiography Brain/drug effects/growth & development/*metabolism Caudate Nucleus/metabolism Iodine Radioisotopes Male Olfactory Bulb/metabolism Organ Specificity Putamen/metabolism Rats Rats, Sprague-Dawley Receptors, Oxytocin/drug effects/*metabolism Testosterone/*pharmacology Ventromedial Hypothalamic Nucleus/metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 13:31
Dernière modification de la notice
20/08/2019 13:42
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