Interet et limitations du concept de demi-vie d'elimination. [Importance and limitations of metabolic drug half-life]

Détails

ID Serval
serval:BIB_13650A69F786
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Interet et limitations du concept de demi-vie d'elimination. [Importance and limitations of metabolic drug half-life]
Périodique
Schweizerische Rundschau fur Medizin Praxis
Auteur(s)
Buclin  T., Biollaz  J.
ISSN
1013-2058 (Print)
Statut éditorial
Publié
Date de publication
10/1997
Volume
86
Numéro
43
Pages
1693-7
Notes
English Abstract
Journal Article
Review --- Old month value: Oct 22
Résumé
Among the pharmacokinetic concepts, the elimination half-life is most frequently used to describe the fate of a drug in the organism. The fact is often neglected, that the half-life depends on various physiological processes (organ clearances, distribution, occasionally absorption or binding to macromolecules). In many situations, the half-life has little to do with the duration of the effect which may depend on effective concentrations, equilibration delays at site of action, indirect response mechanisms, tolerance, or appearance of active metabolites. Finally, the half-life represents an ambiguous criterion for the choice of drugs: short (or long) half-life can be considered either advantageous or disadvantageous, according to endpoints selected.
Mots-clé
Drug Evaluation Drug Labeling Education, Medical Half-Life Humans Metabolic Clearance Rate/physiology *Pharmacokinetics
Pubmed
Création de la notice
25/01/2008 11:41
Dernière modification de la notice
20/08/2019 13:41
Données d'usage