Functional neurological signs in hypermobile Ehlers-Danlos syndrome and hypermobile spectrum disorders with suspected neuropathic pain.

Détails

ID Serval
serval:BIB_13525A4249FB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Functional neurological signs in hypermobile Ehlers-Danlos syndrome and hypermobile spectrum disorders with suspected neuropathic pain.
Périodique
Brain and behavior
Auteur⸱e⸱s
Fernandez A., Jaquet M., Aubry-Rozier B., Suter M., Aybek S., Berna C.
ISSN
2162-3279 (Electronic)
Statut éditorial
Publié
Date de publication
02/2024
Peer-reviewed
Oui
Volume
14
Numéro
2
Pages
e3441
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) are connective tissue disorders characterized by generalized joint hypermobility, associated with chronic pain and several symptoms, such as fatigue, dysautonomia, as well as psychiatric co-morbidities. Clinical observations of unusual manifestations during systematic sensory testing raised the question of a possible co-existence with a functional neurological disorder (FND). Hence, this study aimed to assess the presence of positive functional neurological signs (FNS) in a cohort of patients with hEDS/HSD.
The clinical data of hEDS/HSD patients (N = 24) were retrospectively analyzed and compared to a prospectively recruited age-/sex-matched healthy control group (N = 22). Four motor- and three sensory-positive FNS were assessed.
Twenty-two patients (92%) presented at least one motor or sensory FNS. Five patients (21%) presented only a single FNS, 14 presented between 2 and 4 FNS (58%), and 3 patients presented 5 or more FNS (12%). None of the healthy controls presented motor FNS, and only two presented a sensory FNS.
The presence of FNS in hEDS/HSD deserves better clinical detection and formal diagnosis of FND to offer more adequate care in co-morbid situations. In fact, FND can severely interfere with rehabilitation efforts in hEDS/HSD, and FND-targeted physical therapy should perhaps be combined with EDS/HSD-specific approaches.
Mots-clé
Humans, Retrospective Studies, Ehlers-Danlos Syndrome/complications, Ehlers-Danlos Syndrome/diagnosis, Joint Instability/complications, Joint Instability/diagnosis, Neuralgia, chronic pain, functional neurological disorder, functional neurological positive signs, hypermobile Ehlers-Danlos syndrome, hypermobile spectrum disorder
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/03/2024 14:11
Dernière modification de la notice
26/03/2024 8:11
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