Specific, uncompetitive inhibition of beta-galactosidases by a 5,6-isopropylidenedioxyfuro[2,3-d]isoxazole-3-methanol derivative.

Détails

ID Serval
serval:BIB_13374
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Specific, uncompetitive inhibition of beta-galactosidases by a 5,6-isopropylidenedioxyfuro[2,3-d]isoxazole-3-methanol derivative.
Périodique
Bioorganic and Medicinal Chemistry Letters
Auteur(s)
Schaller C., Demange R., Picasso S., Vogel P.
ISSN
0960-894X (Print)
ISSN-L
0960-894X
Statut éditorial
Publié
Date de publication
1999
Volume
9
Numéro
2
Pages
277-278
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
(-)-(3aS,5S,6S.6aR)-3a,5,6,6a-Tetrahydro-5,6-isopropylide nedioxyfuro [2,3-d]isoxazole-3-methanol ((-)-5) has been tested toward 25 glycohydrolases and found to inhibit beta-galactosidase from Aspergillus niger (Ki = 18 microM) and that from Aspergillus orizae (Ki = 72 microM). Hydrolysis of the acetonide or exchange of CH2OH group for a CHO, CH2OMe or a CH2OMOM group suppresses the inhibitory activity.
Mots-clé
Aspergillus/chemistry, Dose-Response Relationship, Drug, Furans/pharmacology, Hydrogen-Ion Concentration, Hydrolysis, Inhibitory Concentration 50, Isoxazoles/pharmacology, Magnetic Resonance Spectroscopy, beta-Galactosidase/antagonists & inhibitors
Pubmed
Création de la notice
19/11/2007 9:33
Dernière modification de la notice
20/08/2019 12:41
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