Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.

Détails

ID Serval
serval:BIB_131A9EB0C182
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.
Périodique
Nature Medicine
Auteur(s)
Apetoh L., Ghiringhelli F., Tesniere A., Obeid M., Ortiz C., Criollo A., Mignot G., Maiuri M.C., Ullrich E., Saulnier P., Yang H., Amigorena S., Ryffel B., Barrat F.J., Saftig P., Levi F., Lidereau R., Nogues C., Mira J.P., Chompret A., Joulin V., Clavel-Chapelon F., Bourhis J., André F., Delaloge S., Tursz T., Kroemer G., Zitvogel L.
ISSN
1078-8956 (Print)
ISSN-L
1078-8956
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
13
Numéro
9
Pages
1050-1059
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Conventional cancer treatments rely on radiotherapy and chemotherapy. Such treatments supposedly mediate their effects via the direct elimination of tumor cells. Here we show that the success of some protocols for anticancer therapy depends on innate and adaptive antitumor immune responses. We describe in both mice and humans a previously unrecognized pathway for the activation of tumor antigen-specific T-cell immunity that involves secretion of the high-mobility-group box 1 (HMGB1) alarmin protein by dying tumor cells and the action of HMGB1 on Toll-like receptor 4 (TLR4) expressed by dendritic cells (DCs). During chemotherapy or radiotherapy, DCs require signaling through TLR4 and its adaptor MyD88 for efficient processing and cross-presentation of antigen from dying tumor cells. Patients with breast cancer who carry a TLR4 loss-of-function allele relapse more quickly after radiotherapy and chemotherapy than those carrying the normal TLR4 allele. These results delineate a clinically relevant immunoadjuvant pathway triggered by tumor cell death.
Mots-clé
Animals, Antineoplastic Agents/therapeutic use, Bone Neoplasms/drug therapy, Cell Line, Tumor, Colonic Neoplasms/drug therapy, Colonic Neoplasms/radiotherapy, Disease Models, Animal, Humans, Mice, Mice, Inbred BALB C, Neoplasms/drug therapy, Neoplasms/radiotherapy, Organoplatinum Compounds/therapeutic use, Osteosarcoma/drug therapy, Pyridines/therapeutic use, Toll-Like Receptor 4/immunology
Pubmed
Web of science
Création de la notice
01/12/2014 18:28
Dernière modification de la notice
20/08/2019 13:41
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