Biomarkers of Cerebral Damage in Fatal Hypothermia: Preliminary Results.

Détails

ID Serval
serval:BIB_131345FF7979
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Biomarkers of Cerebral Damage in Fatal Hypothermia: Preliminary Results.
Périodique
The American journal of forensic medicine and pathology
Auteur⸱e⸱s
Morleo B., Teresinski G., Rousseau G., Tse R., Tettamanti C., Augsburger M., Palmiere C.
ISSN
1533-404X (Electronic)
ISSN-L
0195-7910
Statut éditorial
Publié
Date de publication
09/2019
Peer-reviewed
Oui
Volume
40
Numéro
3
Pages
242-245
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The identification of hypothermia as the cause of death remains challenging in forensic pathology because of unspecific radiological, morphological, and biochemical results. Hyperemia, edema, and petechial hemorrhages within the cerebral parenchyma were described in cases of death by hypothermia. On the other hand, the effect of low temperatures in the brain has been speculated to cause local injuries on a cellular level with potential occurrences of necrosis and inflammation. In the study herein described, endocan, alkaline phosphatase, neuron-specific enolase, S100 protein subunit B, glial fibrillary acidic protein, and C-reactive protein were measured in postmortem serum from femoral blood and cerebrospinal fluid in a series of hypothermia fatalities and control cases. The combination of data collected failed to identify a specific biochemical profile for death by hypothermia in postmortem serum and/or the cerebrospinal fluid, thus suggesting that an alternative panel of brain damage biomarkers indicative of diffuse hypoxic brain injury needs to be defined in hypothermia fatalities.
Mots-clé
Adult, Aged, Alkaline Phosphatase/blood, Alkaline Phosphatase/cerebrospinal fluid, Biomarkers/blood, Biomarkers/cerebrospinal fluid, C-Reactive Protein/analysis, Case-Control Studies, Female, Forensic Medicine, Glial Fibrillary Acidic Protein/blood, Glial Fibrillary Acidic Protein/cerebrospinal fluid, Humans, Hypothermia/blood, Hypothermia/cerebrospinal fluid, Hypoxia-Ischemia, Brain/diagnosis, Male, Middle Aged, Neoplasm Proteins/blood, Neoplasm Proteins/cerebrospinal fluid, Phosphopyruvate Hydratase/blood, Phosphopyruvate Hydratase/cerebrospinal fluid, Proteoglycans/blood, Proteoglycans/cerebrospinal fluid, S100 Calcium Binding Protein beta Subunit/blood, S100 Calcium Binding Protein beta Subunit/cerebrospinal fluid, Young Adult
Pubmed
Web of science
Création de la notice
11/09/2019 21:09
Dernière modification de la notice
23/01/2020 6:26
Données d'usage