HLA and genetic susceptibility to sleepwalking.
Détails
ID Serval
serval:BIB_12E7219C5F76
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
HLA and genetic susceptibility to sleepwalking.
Périodique
Molecular Psychiatry
ISSN
1359-4184[print], 1359-4184[linking]
Statut éditorial
Publié
Date de publication
01/2003
Volume
8
Numéro
1
Pages
114-117
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
HLA-DQB1 typing was performed in 60 Caucasian subjects with sleepwalking (SW) disorder and their families and 60 ethnically matched subjects without any diagnosed sleep disorder. A total of 21 sleepwalkers (35.0%) were DQB1*0501 positive vs eight (13.3%) controls (P = 0.0056; odds ratio = 3.5, 95% CI = 1.4-8.7). The family data for all HLA subtypes were further assessed for allelic association with SW using the transmission-disequilibrium test. A significant excess transmission was observed for DQB1*05 and *04 alleles in familial cases, strongly suggesting that a DQB1 polymorphic amino acid might be more tightly associated than any single allele. Sequence screening revealed that Ser74 in the second exon shared by all DQB1*05 and *04 was 20 times transmitted against 4 times non-transmitted (P = 0.001) in familial cases of SW. Thus, together with narcolepsy and REM sleep behavior disorder, these findings suggest that specific DQB1 genes are implicated in disorders of motor control during sleep.
Mots-clé
Adolescent, Adult, Aged, Child, Child, Preschool, Female, Genetic Predisposition to Disease, HLA-DQ Antigens/genetics, Histocompatibility Testing, Humans, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Restriction Fragment Length, Somnambulism/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:55
Dernière modification de la notice
20/08/2019 13:41