HLA and genetic susceptibility to sleepwalking.

Détails

ID Serval
serval:BIB_12E7219C5F76
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
HLA and genetic susceptibility to sleepwalking.
Périodique
Molecular Psychiatry
Auteur(s)
Lecendreux M., Bassetti C., Dauvilliers Y., Mayer G., Neidhart E., Tafti M.
ISSN
1359-4184[print], 1359-4184[linking]
Statut éditorial
Publié
Date de publication
01/2003
Volume
8
Numéro
1
Pages
114-117
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
HLA-DQB1 typing was performed in 60 Caucasian subjects with sleepwalking (SW) disorder and their families and 60 ethnically matched subjects without any diagnosed sleep disorder. A total of 21 sleepwalkers (35.0%) were DQB1*0501 positive vs eight (13.3%) controls (P = 0.0056; odds ratio = 3.5, 95% CI = 1.4-8.7). The family data for all HLA subtypes were further assessed for allelic association with SW using the transmission-disequilibrium test. A significant excess transmission was observed for DQB1*05 and *04 alleles in familial cases, strongly suggesting that a DQB1 polymorphic amino acid might be more tightly associated than any single allele. Sequence screening revealed that Ser74 in the second exon shared by all DQB1*05 and *04 was 20 times transmitted against 4 times non-transmitted (P = 0.001) in familial cases of SW. Thus, together with narcolepsy and REM sleep behavior disorder, these findings suggest that specific DQB1 genes are implicated in disorders of motor control during sleep.
Mots-clé
Adolescent, Adult, Aged, Child, Child, Preschool, Female, Genetic Predisposition to Disease, HLA-DQ Antigens/genetics, Histocompatibility Testing, Humans, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Restriction Fragment Length, Somnambulism/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 15:55
Dernière modification de la notice
20/08/2019 12:41
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