Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer.

Détails

ID Serval
serval:BIB_12B315FCA5BE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer.
Périodique
Nature communications
Auteur(s)
Kotagiri N., Cooper M.L., Rettig M., Egbulefu C., Prior J., Cui G., Karmakar P., Zhou M., Yang X., Sudlow G., Marsala L., Chanswangphuwana C., Lu L., Habimana-Griffin L., Shokeen M., Xu X., Weilbaecher K., Tomasson M., Lanza G., DiPersio J.F., Achilefu S.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
18/01/2018
Peer-reviewed
Oui
Volume
9
Numéro
1
Pages
275
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Most cancer patients succumb to disseminated disease because conventional systemic therapies lack spatiotemporal control of their toxic effects in vivo, particularly in a complicated milieu such as bone marrow where progenitor stem cells reside. Here, we demonstrate the treatment of disseminated cancer by photoactivatable drugs using radiopharmaceuticals. An orthogonal-targeting strategy and a contact-facilitated nanomicelle technology enabled highly selective delivery and co-localization of titanocene and radiolabelled fluorodeoxyglucose in disseminated multiple myeloma cells. Selective ablation of the cancer cells was achieved without significant off-target toxicity to the resident stem cells. Genomic, proteomic and multimodal imaging analyses revealed that the downregulation of CD49d, one of the dimeric protein targets of the nanomicelles, caused therapy resistance in small clusters of cancer cells. Similar treatment of a highly metastatic breast cancer model using human serum albumin-titanocene formulation significantly inhibited cancer growth. This strategy expands the use of phototherapy for treating previously inaccessible metastatic disease.

Pubmed
Web of science
Open Access
Oui
Création de la notice
31/01/2018 11:10
Dernière modification de la notice
20/08/2019 12:40
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