Thyroid and pituitary secretory disorders in streptozotocin-diabetic rats are associated with severe structural changes of these glands

Détails

ID Serval
serval:BIB_12A3B6651298
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Thyroid and pituitary secretory disorders in streptozotocin-diabetic rats are associated with severe structural changes of these glands
Périodique
Virchows Archiv. B, Cell Pathology Including Molecular Pathology
Auteur(s)
Bestetti  G. E., Reymond  M. J., Perrin  I. V., Kniel  P. C., Lemarchand-Beraud  T., Rossi  G. L.
ISSN
0340-6075
Statut éditorial
Publié
Date de publication
1987
Volume
53
Numéro
2
Pages
69-78
Notes
Journal Article
Research Support, Non-U.S. Gov't
Résumé
Streptozotocin diabetes in rats is associated with reduced function of the hypothalamo-pituitary-thyroid axis. The structure and hormone secretion of the thyroid and pituitary glands were studied in adult male rats 1 month after streptozotocin injection. The thyroid of diabetic rats was characterized by decreased follicle area and epithelial thickness. By electron microscopy, thyroid epithelial cells were characterized by flattened and almost empty rough endoplasmic reticulum cisternae, scanty exocytotic apical and endocytotic vesicles as well as degenerate mitochondria and rough endoplasmic reticulum. By immunohistochemistry, intracolloidal thyroglobulin and T3 as well as intraepithelial thyroglobulin were reduced. Electron microscopic and immunohistochemical analysis of pituitary glands showed that in diabetic rats thyrotrophs were mostly of type II, and the number of thyrotrophs (type I + type II) was greater than in controls. By radioimmunoassay (RIA), plasma T3, T4, and TSH levels were markedly reduced, and the TSH response to TRH was deficient in diabetic animals. The pituitary TSH concentration was increased, as expected from the morphological data. This study demonstrates severe structural changes in the thyroid and pituitary glands of diabetic rats which are accompanied by marked alterations of their secretory activity.
Mots-clé
Animals Diabetes Mellitus, Experimental/*pathology/physiopathology Histocytochemistry Immunoenzyme Techniques Male Microscopy, Electron Organ Size Pituitary Gland/*pathology/secretion Pituitary Hormones/secretion Rats Rats, Inbred Strains Thyroid Gland/*pathology/secretion Thyroid Hormones/secretion Thyrotropin/blood Thyroxine/blood Triiodothyronine/blood
Pubmed
Web of science
Création de la notice
11/02/2008 15:12
Dernière modification de la notice
20/08/2019 13:40
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