Transplantation rénale pédiatrique: expérience lausannoise de 1971 à 1998 [Pediatric renal transplantation: Experience in Lausanne 1971 to 1998].

Détails

ID Serval
serval:BIB_12766
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Transplantation rénale pédiatrique: expérience lausannoise de 1971 à 1998 [Pediatric renal transplantation: Experience in Lausanne 1971 to 1998].
Périodique
Schweizerische Medizinische Wochenschrift
Auteur(s)
Cachat F., Mosimann F., Guignard J.P.
ISSN
0036-7672 (Print)
ISSN-L
0036-7672
Statut éditorial
Publié
Date de publication
1999
Volume
129
Numéro
36
Pages
1280-1286
Langue
français
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Résumé
AIMS OF THE STUDY: Analysis of indications and results of paediatric renal transplantation in a single centre, before and after the introduction of cyclosporine A (CSA).
METHODS: Historical retrospective study.
RESULTS: 19 transplantations were performed in 14 patients (5 second grafts) between 1971 and 1987 (group I). 13 patients were transplanted between 1988 and 1998 (no second transplant) (group II). In group II, all the patients had immunosuppression with CSA, but none in group I. Group II, with CSA, showed better renal survival than patients without CSA. In group I, obstructive uropathies (posterior urethral valves, pyelo-ureteral junction stenosis, vesico-ureteral reflux) represent a common cause (35%) of terminal chronic renal failure (TCRF), whereas in group II they represent only 15% of the causes and chronic glomerulonephritis is the most common cause (69%) of TCRF. Acute and chronic graft rejections were the cause of 9 and 1 graft losses in group I and II respectively. Living related donors account for 14% of all renal transplantations in group I and 46% in group II.
CONCLUSIONS: The incidence of paediatric patients referred to Lausanne for TCRF is stable. We have observed a constant and steady decrease in obstructive uropathies leading to TCRF and renal transplantations, whereas glomerulonephritis are increasingly frequent. Graft survival has much improved since the introduction of cyclosporine A, without an increase in morbidity. In carefully selected cases, intrafamilial renal transplantation provides good results and helps to shorten the time spent on dialysis.
Mots-clé
Adolescent, Child, Cyclosporine/therapeutic use, Female, Graft Survival, Hospitals, University/statistics & numerical data, Humans, Immunosuppressive Agents/therapeutic use, Kidney Failure, Chronic/etiology, Kidney Failure, Chronic/surgery, Kidney Transplantation/mortality, Kidney Transplantation/physiology, Living Donors/statistics & numerical data, Male, Reoperation/statistics & numerical data, Retrospective Studies, Survival Analysis, Switzerland, Tissue Donors/statistics & numerical data
Pubmed
Web of science
Création de la notice
19/11/2007 12:04
Dernière modification de la notice
20/08/2019 12:40
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