Novel approaches in anti-arenaviral drug development.

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Etat: Public
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ID Serval
serval:BIB_1242EF878AD9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Novel approaches in anti-arenaviral drug development.
Périodique
Virology
Auteur(s)
Lee A.M., Pasquato A., Kunz S.
ISSN
1096-0341 (Electronic)
ISSN-L
0042-6822
Statut éditorial
Publié
Date de publication
2011
Volume
411
Numéro
2
Pages
163-169
Langue
anglais
Résumé
Hemorrhagic fevers caused by arenaviruses are among the most devastating emerging human diseases. Considering the number of individuals affected, the current lack of a licensed vaccine, and the limited therapeutic options, arenaviruses are arguably among the most neglected tropical pathogens and the development of efficacious anti-arenaviral drugs is of high priority. Over the past years significant efforts have been undertaken to identify novel potent inhibitors of arenavirus infection. High throughput screening of small molecule libraries employing pseudotype platforms led to the discovery of several potent and broadly active inhibitors of arenavirus cell entry that are effective against the major hemorrhagic arenaviruses. Mechanistic studies revealed that these novel entry inhibitors block arenavirus membrane fusion and provided novel insights into the unusual mechanism of this process. The success of these approaches highlights the power of small molecule screens in antiviral drug discovery and establishes arenavirus membrane fusion as a robust drug target. These broad screenings have been complemented by strategies targeting cellular factors involved in productive arenavirus infection. Approaches targeting the cellular protease implicated in maturation of the fusion-active viral envelope glycoprotein identified the proteolytic processing of the arenavirus glycoprotein precursor as a novel and promising target for anti-arenaviral strategies.
Pubmed
Web of science
Open Access
Oui
Création de la notice
07/04/2011 8:45
Dernière modification de la notice
20/08/2019 12:40
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