Efficient gene delivery and selective transduction of astrocytes in the mammalian brain using viral vectors.

Détails

Ressource 1Télécharger: BIB_1224EB8FE14B.P001.pdf (659.96 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_1224EB8FE14B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Efficient gene delivery and selective transduction of astrocytes in the mammalian brain using viral vectors.
Périodique
Frontiers in Cellular Neuroscience
Auteur(s)
Merienne N., Le Douce J., Faivre E., Déglon N., Bonvento G.
ISSN
1662-5102 (Electronic)
ISSN-L
1662-5102
Statut éditorial
Publié
Date de publication
2013
Volume
7
Pages
106
Langue
anglais
Notes
Publication types: Journal Article Publication Status: epublish
Résumé
Astrocytes are now considered as key players in brain information processing because of their newly discovered roles in synapse formation and plasticity, energy metabolism and blood flow regulation. However, our understanding of astrocyte function is still fragmented compared to other brain cell types. A better appreciation of the biology of astrocytes requires the development of tools to generate animal models in which astrocyte-specific proteins and pathways can be manipulated. In addition, it is becoming increasingly evident that astrocytes are also important players in many neurological disorders. Targeted modulation of protein expression in astrocytes would be critical for the development of new therapeutic strategies. Gene transfer is valuable to target a subpopulation of cells and explore their function in experimental models. In particular, viral-mediated gene transfer provides a rapid, highly flexible and cost-effective, in vivo paradigm to study the impact of genes of interest during central nervous system development or in adult animals. We will review the different strategies that led to the recent development of efficient viral vectors that can be successfully used to selectively transduce astrocytes in the mammalian brain.
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/08/2013 9:17
Dernière modification de la notice
20/08/2019 13:40
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