Morphology of transmyocardial laser revascularisation. [19]

Détails

ID Serval
serval:BIB_12205
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Morphology of transmyocardial laser revascularisation. [19]
Titre de la conférence
34th Congress of the European Society for Surgical Research
Auteur(s)
Mueller X., Tevaearai H., Genton C., von Segesser L.
ISBN
1421-9921
Statut éditorial
Publié
Date de publication
1999
Volume
31
Série
European Surgical Research
Pages
10
Langue
anglais
Notes
Introduction: Transmyocardial Laser Revascularisation (TMLR) has emerged as a therapeutic modality for angina refractory to conventional therapy. Initially, blood flowing from the ventricular cavity through the patent channels was thought to be the underlying mechanism. This study analyses longterm morphology of the laser channels in the pig. Methods: Fifteen pigs were randomised either to ligation of marginal arteries (n D 5), or TMLR of the left lateral wall (n D 5), or a control group (n D 5). Animals were sacrificed after 28 days. The channel regions were sliced perpendicularly to the channels. A computed morphometrical analysis was performed for the surface areas of the channels and for their vascular density, expressed as number of vascular structures per mm2 (_1 SD). Results: Macroscopically, all the endocardial openings of the channels were occluded. Histologically the channels showed a central area of necrosis (5 _ 1%) surrounded by scar tissue (95 _ 1%). There was no central lumen. Vascular density of scar tissue was significantly larger than that of myocardial infarction alone: 49:6 _ 12:8/mm2 vs 25:5 _ 8:6/mm2 (p < 0:0001). The area immediately adjacent to the channels exhibited a density of 6:3 _ 1:7/mm2 which was similar to that of normal myocardial tissue (5:2 _ 1:9/mm2). Discussion and Conclusion: Laser channels are occluded by scar tissue with a vascular density larger than that of myocardial infarction alone. Thus channel patency is unlikely to be the explanation for clinical improvement. However neovascularisation is a potential mechanism requiring further evaluation.
Création de la notice
19/11/2007 13:03
Dernière modification de la notice
20/08/2019 13:39
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