The heme moiety of cytochrome c is an autoreactive Ir gene-restricted T cell epitope

Détails

ID Serval
serval:BIB_11F5F2502D6E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The heme moiety of cytochrome c is an autoreactive Ir gene-restricted T cell epitope
Périodique
Journal of Experimental Medicine
Auteur(s)
Cooper  H. M., Corradin  G., Paterson  Y.
ISSN
0022-1007 (Print)
Statut éditorial
Publié
Date de publication
09/1988
Volume
168
Numéro
3
Pages
1127-43
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Sep 1
Résumé
In these studies, we have shown that the heme moiety of cyt c is a dominant T cell epitope that induces a large proliferative response in lymph node T cells derived from SJL and B10.A mice when presented on either unfixed or fixed syngeneic APCs. Not only is this vigorous response observed for cyt c-primed T cell populations but also for populations obtained from naive SJL or B10.A mice. The reactivity to the heme moiety falls under strict MHC restriction, in that it is present only in murine strains bearing either the I-Ak or I-As molecule and can be blocked by antibodies specific for these class II molecules. Therefore, these findings require that the current models describing the nature of T cell epitopes be extended to include nonpeptide molecules. Furthermore, as the heme moiety is ubiquitous throughout the organism, although sequestered within proteins, the existence of heme-reactive T cell populations in unprimed animals provides another example of the existence of self-reactive T cell clones.
Mots-clé
Animals Antibodies, Monoclonal/immunology Antigen-Presenting Cells/immunology/radiation effects Autoantigens/*immunology Cytochrome c Group/*immunology Epitopes *Genes, MHC Class II Heme/*immunology Immunologic Techniques Lymphocyte Activation Macromolecular Substances Mice Molecular Structure Serum Albumin Spleen/immunology T-Lymphocytes/*immunology
Pubmed
Web of science
Création de la notice
24/01/2008 15:55
Dernière modification de la notice
20/08/2019 13:39
Données d'usage