The association carbamazepine-mianserin in opiate withdrawal: a double blind pilot study versus clonidine.

Détails

ID Serval
serval:BIB_11EDBF148497
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The association carbamazepine-mianserin in opiate withdrawal: a double blind pilot study versus clonidine.
Périodique
Pharmacological research
Auteur⸱e⸱s
Bertschy G., Bryois C., Bondolfi G., Velardi A., Budry P., Dascal D., Martinet C., Baettig D., Baumann P.
ISSN
1043-6618 (Print)
ISSN-L
1043-6618
Statut éditorial
Publié
Date de publication
05/1997
Peer-reviewed
Oui
Volume
35
Numéro
5
Pages
451-456
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Our clinic has fortuitously developed the therapeutic use of the association of mianserin (maximum daily dose 90 mg) and carbamazepine (maximum daily dose 400 mg) in opiate withdrawal management. If animal studies have suggested efficacy of mianserin in such indication, no human studies have been performed. To test the efficacy of such an association, a comparison was made to clonidine (maximum daily dose 0.600 mg) in a one week treatment period according to a double blind pilot study design. Thirty-two patients were included (16 in each treatment group). The two treatments did not differ in the intensity of the withdrawal, according to the rate of retention in treatment and symptoms, and the psychic distress which were auto-evaluated every other day with the Opiate Withdrawal Questionnaire and several Visual Analog Scales (VAS). The clonidine group, however, scored significantly higher (P < 0.05) on the VAS rating of the global feeling of satisfaction on the last day. The patients in the mianserin group fortuitously had a moderately lower number of daily heroin intakes but there was no significant correlation between this variable and the global OWQ scores on Days 1, 3, 5 and 7. Given the size of the groups, we cannot conclude that the association carbamazepine-mianserin is as effective as clonidine, but a real effectiveness is probable. A study versus placebo would be necessary to draw more definitive conclusions.
Mots-clé
Adult, Analgesics, Non-Narcotic/therapeutic use, Antidepressive Agents, Second-Generation/therapeutic use, Carbamazepine/therapeutic use, Clonidine/therapeutic use, Double-Blind Method, Drug Combinations, Female, Hemodynamics/drug effects, Heroin Dependence/complications, Heroin Dependence/psychology, Humans, Male, Mianserin/therapeutic use, Pilot Projects, Psychiatric Status Rating Scales, Substance Withdrawal Syndrome/drug therapy, Substance Withdrawal Syndrome/psychology
Pubmed
Web of science
Création de la notice
12/01/2021 16:16
Dernière modification de la notice
15/04/2023 5:51
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