Excitatory amino acids stimulate aerobic glycolysis in astrocytes via an activation of the Na+/K+ ATPase

Détails

ID Serval
serval:BIB_11D553EDBC48
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Excitatory amino acids stimulate aerobic glycolysis in astrocytes via an activation of the Na+/K+ ATPase
Périodique
Developmental Neuroscience
Auteur(s)
Pellerin  L., Magistretti  P. J.
ISSN
0378-5866 (Print)
Statut éditorial
Publié
Date de publication
1996
Volume
18
Numéro
5-6
Pages
336-42
Notes
Journal Article
Research Support, Non-U.S. Gov't
Résumé
Astrocytes appear to be ideally localized to couple neuronal activity to energy metabolism. First, specialized processes, the astrocytic end-feet surround blood vessels, the source of glucose for the brain. Second, other processes ensheath synapses and express receptors and transporters for various neurotransmitters, endowing astrocytes with the capacity to 'sense' synaptic activity. We have previously described the stimulation by L-glutamate of glucose utilization by astrocytes, monitored by 2-deoxyglucose uptake and phosphorylation. Here we have further characterized the pharmacological characteristics and molecular mechanisms of this action, which involve a massive influx of Na+ as a result of the cotransport of the amino acid with Na+, by Na(+)-dependent transporters and a subsequent activation of the Na+/K+ ATPase. To fuel the ATPase, glucose is processed glycolytically thus leading to increased lactate production. Since excitatory amino acids are released during activation by cortical afferents, these data reveal a simple mechanism for coupling neuronal activity to glucose utilization and provide further evidence for the concept of a transient stimulation of aerobic glycolysis during activation occurring preferentially in astrocytes.
Mots-clé
Aerobiosis Animals Astrocytes/*metabolism Enzyme Activation Excitatory Amino Acids/*pharmacology Glucose/metabolism Glycolysis/*drug effects Mice Mice, Inbred Strains Na(+)-K(+)-Exchanging ATPase/*metabolism Sodium/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 14:17
Dernière modification de la notice
20/08/2019 13:39
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