Quantitative genetics of sleep in inbred mice.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_11C27EA6C67D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Quantitative genetics of sleep in inbred mice.
Périodique
Dialogues in Clinical Neuroscience
Auteur(s)
Tafti M.
ISSN
1294-8322[print]
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
9
Numéro
3
Pages
273-278
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
The timing and the organization of sleep architecture are mainly controlled by the circadian system, while sleep need and intensity are regulated by a homeostatic process. How independent these two systems are in regulating sleep is not well understood. In contrast to the impressive progress in the molecular genetics of circadian rhythms, little is known about the molecular basis of sleep. Nevertheless, as summarized here, phenotypic dissection of sleep into its most basic aspects can be used to identify both the single major genes and small effect quantitative trait loci involved. Although experimental models such as the mouse are more readily amenable to genetic analysis of sleep, similar approaches can be applied to humans.
Mots-clé
Animals, Circadian Rhythm/genetics, Electroencephalography/methods, Gene Expression Regulation/physiology, Mice, Mice, Inbred Strains/physiology, Quantitative Trait Loci, Sleep/genetics
Pubmed
Création de la notice
24/01/2008 16:55
Dernière modification de la notice
20/08/2019 13:39
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