Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_119EF928F3F4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
Périodique
Nature Genetics
Auteur(s)
Martin M. P., Qi Y., Gao X., Yamada E., Martin J. N., Pereyra F., Colombo S., Brown E. E., Shupert W. L., Phair J., Goedert J. J., Buchbinder S., Kirk G. D., Telenti A., Connors M., O'Brien S. J., Walker B. D., Parham P., Deeks S. G., McVicar D. W., Carrington M.
ISSN
1061-4036 (Print)
Statut éditorial
Publié
Date de publication
06/2007
Peer-reviewed
Oui
Volume
39
Numéro
6
Pages
733-40
Langue
anglais
Notes
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't --- Old month value: Jun
Résumé
Allotypes of the natural killer (NK) cell receptor KIR3DL1 vary in both NK cell expression patterns and inhibitory capacity upon binding to their ligands, HLA-B Bw4 molecules, present on target cells. Using a sample size of over 1,500 human immunodeficiency virus (HIV)+ individuals, we show that various distinct allelic combinations of the KIR3DL1 and HLA-B loci significantly and strongly influence both AIDS progression and plasma HIV RNA abundance in a consistent manner. These genetic data correlate very well with previously defined functional differences that distinguish KIR3DL1 allotypes. The various epistatic effects observed here for common, distinct KIR3DL1 and HLA-B Bw4 combinations are unprecedented with regard to any pair of genetic loci in human disease, and indicate that NK cells may have a critical role in the natural history of HIV infection.
Mots-clé
Alleles Cohort Studies Disease Progression HIV Infections/genetics/*immunology/metabolism HIV-1/*genetics HLA-B Antigens/genetics/immunology/*metabolism Humans Immunity, Natural Killer Cells, Natural/immunology RNA, Viral/blood/genetics Receptors, Immunologic/genetics/immunology/*metabolism Viral Load
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 15:46
Dernière modification de la notice
20/08/2019 13:39
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