Different degrees of ischaemic injury in the right and left ventricle in cases of severe, nonfatal, pulmonary embolism.

Détails

ID Serval
serval:BIB_11807CA8F1EB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Different degrees of ischaemic injury in the right and left ventricle in cases of severe, nonfatal, pulmonary embolism.
Périodique
International Journal of Legal Medicine
Auteur(s)
Fracasso T., Schrag B., Sabatasso S., Lobrinus J.A., Schmeling A., Mangin P.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
129
Numéro
3
Pages
525-529
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Pulmonary fat embolism (PFE) is a common complication of blunt force traumas with bone fractures. Severe forms cause impedance to right ventricular (RV) ejection, with eventual right heart ischaemia and failure. In a prospective study, we have investigated 220 consecutive autopsy cases (73 females, 147 males, mean age 52.1 years, min 14 years, max 91 years). PFE was detected in 52 cases that were divided into three groups according to the degree of PFE (1-3). A fourth group of cases of violent death without PFE was used for comparison. In each case, histology (H&E, Masson) and immunohistochemistry (fibronectin and C5b-9) were performed on six cardiac samples (anterior, lateral and posterior wall of both ventricles). The degree of cardiac damage was registered in each sample and the mean degree of damage was calculated in each case at the RV and left ventricle (LV). Moreover, a parameter ∆ that is the difference between the mean damage at the RV and the LV was calculated in each case. The results were compared within each group and between the groups. In the present study, we could not detect prevalent RV damage in cases of high degree PFE as we did in our previous investigation. In the group PFE3 the difference of the degree of damage between the RV and LV was higher than the one observed in the groups PFE0-2 with the antibody anti-fibronectin. Prevalent right ventricular stress in cases of severe PFE may explain this observation.
Pubmed
Web of science
Création de la notice
24/10/2014 14:46
Dernière modification de la notice
20/08/2019 13:39
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