Successful combined heart and kidney transplantation in a patient with sickle-cell anemia.

Détails

ID Serval
serval:BIB_116A2406057A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Successful combined heart and kidney transplantation in a patient with sickle-cell anemia.
Périodique
The Journal of heart and lung transplantation
Auteur(s)
Audard V., Grimbert P., Kirsch M., Habibi M.A., Lang P., Remy P., Abbou C., Loisance D., Benaiem N., Bachir D., Vermes E.
ISSN
1557-3117 (Electronic)
ISSN-L
1053-2498
Statut éditorial
Publié
Date de publication
08/2006
Peer-reviewed
Oui
Volume
25
Numéro
8
Pages
993-996
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
Little is known about the management of dual-organ transplantation for sickle-cell disease (SCD)-related complications. In this case study, we report the successful outcome of combined heart and kidney transplantation in a patient with SCD. The recipient was a 33-year-old man with homozygous SCD, who developed end-stage heart and renal failure requiring combined heart and kidney transplantation. The patient was managed with pre-operative blood transfusion and moderate hypothermic cardiopulmonary bypass, with limited peri-operative complications. During the first 6 months there was one episode of acute heart rejection without concomitant renal rejection. Eighteen months after surgery, the patient is at home without vaso-occlusive crises or septic complications. Heart and renal allograft function is preserved, without coronary artery vasculopathy, but with asymptomatic moderate transplant renal artery stenosis. SCD is managed by periodic transfusion. This case study demonstrates that combined heart and kidney transplantation is feasible in patients with SCD. Careful attention to peri- and post-operative management is required.
Mots-clé
Adult, Anemia, Sickle Cell/complications, Heart Failure/complications, Heart Failure/surgery, Heart Transplantation, Humans, Kidney Failure, Chronic/complications, Kidney Failure, Chronic/surgery, Kidney Transplantation, Male, Remission Induction
Pubmed
Web of science
Création de la notice
29/03/2019 7:27
Dernière modification de la notice
20/08/2019 12:39
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