Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes.

Détails

ID Serval
serval:BIB_115D56E8D31D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes.
Périodique
European Journal of Immunology
Auteur(s)
LeibundGut-Landmann S., Waldburger J.M., Krawczyk M., Otten L.A., Suter T., Fontana A., Acha-Orbea H., Reith W.
ISSN
0014-2980 (Print)
ISSN-L
0014-2980
Statut éditorial
Publié
Date de publication
2004
Volume
34
Numéro
6
Pages
1513-1525
Langue
anglais
Résumé
The class II transactivator (CIITA) has been referred to as the "master control factor" for the expression of MHC class II (MHCII) genes. As our knowledge on the specificity and function of CIITA grows, it is becoming increasingly evident that this sobriquet is entirely justified. First, despite extensive investigations, the major target genes of CIITA remain those implicated in the presentation of antigenic peptides by MHCII molecules. Although other putative target genes have been reported, the contribution of CIITA to their expression remains indirect, controversial or comparatively minor relative to its decisive role as a regulator of MHCII and related genes. Second, the most important parameter dictating MHCII expression is by far the expression pattern of the gene encoding CIITA (MHC2TA). The vast majority of signals that activate or repress MHCII expression under physiological and pathological situations converge on one or more of the three alternative promoters that drive transcription of the MHC2TA gene. In short, with respect to its specificity and its exquisitely controlled pattern of expression, CIITA is by a long stretch the single most important transcription factor for the regulation of genes required for MHCII-restricted antigen-presentation.
Mots-clé
Animals, Antigen Presentation/immunology, Gene Expression Regulation/immunology, Genes, MHC Class II/immunology, Histocompatibility Antigens Class II/genetics, Humans, Mice, Mice, Knockout, Nuclear Proteins/biosynthesis, Nuclear Proteins/genetics, Trans-Activators/biosynthesis, Trans-Activators/genetics, Transcription Factors/immunology, Transcriptional Activation/immunology
Pubmed
Web of science
Création de la notice
24/01/2008 15:48
Dernière modification de la notice
20/08/2019 13:38
Données d'usage