Effect of somatostatin on duodenal glucose absorption in man.

Détails

ID Serval
serval:BIB_113AAFD90A3D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effect of somatostatin on duodenal glucose absorption in man.
Périodique
The Journal of clinical endocrinology and metabolism
Auteur(s)
Féry F., Tappy L., Schneiter P., Devière J., Balasse E.O.
ISSN
0021-972X
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
90
Numéro
7
Pages
4163-9
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
OBJECTIVE: The hyperglycemic hyperinsulinemic clamp technique using intraduodenally infused glucose is an attractive tool for studying postprandial glucose metabolism under strictly controlled conditions. Because it requires the use of somatostatin (SST), we examined, in this study, the effect of SST on intestinal glucose absorption. CONTEXT: Twenty-six normal volunteers were given a constant 3-h intraduodenal infusion of glucose (6 mg.kg(-1).min(-1)) labeled with [2-(3)H]glucose for glucose absorption measurement. During glucose infusion, 19 subjects received iv SST at doses of 10-100 ng.kg(-1).min(-1) plus insulin and glucagon, and seven subjects were studied under control conditions. In the controls, glucose was absorbed at a rate that, after a 20-min lag period, equaled the infusion rate. RESULTS: With all the doses of SST tested, absorption was considerably delayed but equaled the rate of infusion after 3 h. At that time, only 5 +/- 2% of the total amount of infused glucose was unabsorbed in the control subjects vs. 36 +/- 2% (P < 0.001) in the SST-infused subjects. In the latter, the intraluminal residue was almost totally absorbed within 40 min of the cessation of SST infusion. At the lowest dose of SST tested (10 ng.kg(-1).min(-1)), suppression of insulin secretion was incomplete. CONCLUSION: These properties of SST hamper the use of intraduodenal hyperglycemic hyperinsulinemic clamps as a tool for exploring postprandial glucose metabolism.
Mots-clé
Adult, Duodenum, Female, Glucose, Glucose Transporter Type 2, Humans, Intestinal Absorption, Male, Monosaccharide Transport Proteins, Somatostatin
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 14:36
Dernière modification de la notice
20/08/2019 13:38
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