T-cell receptor alpha chain V region polymorphism linked to primary autoimmune hypothyroidism but not Graves' disease

Détails

ID Serval
serval:BIB_1131BFDF740C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
T-cell receptor alpha chain V region polymorphism linked to primary autoimmune hypothyroidism but not Graves' disease
Périodique
Human Immunology
Auteur⸱e⸱s
Weetman  A. P., So  A. K., Roe  C., Walport  M. J., Foroni  L.
ISSN
0198-8859 (Print)
Statut éditorial
Publié
Date de publication
10/1987
Volume
20
Numéro
2
Pages
167-73
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
T-cell receptor alpha- and beta-chain polymorphisms have been investigated in patients with autoimmune thyroid disease. Using a cDNA probe for the T-cell receptor alpha chain, a 1.4-kb V alpha Taq I restriction fragment was found in 25 of 33 patients with autoimmune hypothyroidism compared to 33 of 61 control subjects (p less than 0.05) and 16 of 43 patients with Graves' disease (p less than 0.001 compared to patients with autoimmune hypothyroidism). Moreover, when Graves' patients were divided according to HLA-DR3 status, there was a significantly reduced frequency of the 1.4-kb V alpha fragment in HLA-DR3-negative patients (p less than 0.05 compared to controls). There was no significant association of either thyroid disorder with polymorphisms of the T-cell receptor alpha- or beta-chain-constant region genes, after Taq I and Bgl II digestion, respectively. These results show that inherited variation in T-cell receptor genes, recognizable before any somatic event has taken place, may play a role in susceptibility to autoimmune disease.
Mots-clé
Autoimmune Diseases/*genetics Graves Disease/*genetics Humans Hypothyroidism/*genetics Polymorphism, Restriction Fragment Length Receptors, Antigen, T-Cell/*genetics
Pubmed
Web of science
Création de la notice
25/01/2008 8:38
Dernière modification de la notice
20/08/2019 12:38
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