TDMplus: the combination of TDM, check for drug interactions and genotyping

Détails

ID Serval
serval:BIB_11176496D021
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
TDMplus: the combination of TDM, check for drug interactions and genotyping
Titre de la conférence
5th Regensburg Symposium on Clinical Pharmacology - of Therapeutical Drug Monitoring - 8th Workshop of the TDM Workgroup of AGNP
Auteur(s)
Jaquenoud Sirot Eveline, Baumann Pierre
ISBN
0176-3679
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
41
Série
Pharmacopsychiatry
Pages
A19
Langue
anglais
Notes
SAPHIRID:69092
Résumé
Therapeutic Drug Monitoring (TDM), Drug Interactions checking programs and pharmacogenetic tests are valuable instruments in daily clinical practice's quality assurance. However, routine testing would be expensive and there seems no need for it. Many years work experience in pharmacovigilance and quality assurance in psychiatry led us to develop and apply an algorithm [1]. This decision tree leads in several ,,stop/go" steps from the clinical situation of inefficacy or adverse reaction to measuring and interpreting plasma levels, checking for pharmacokinetic interactions and finally, if indicated, to pharmacogenetic tests with genotyping and/or phenotyping. Genetic results should be noted for future treatments, a ,,pharmacogenetic card" is proposed.
Several clinical cases, mainly from the pharmacovigilance program AMSP, are used to illustrate its practical use: interpretation of plasma levels and metabolic ratios, benefit and limitations of drug interaction programs, indication for pharmacogenetic testing, and examples of other factors influencing drug response.
The interplay of genetics, drug interactions, life style and other personal vulnerabilities like comorbidity make prediction of drug response very complex. The use of TDMplus has proven useful guiding the clinicians in difficult clinical situations and helping elucidating the causality of adverse drug reactions.
Création de la notice
18/09/2008 15:55
Dernière modification de la notice
20/08/2019 12:38
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