Clostridium difficile infection is associated with graft loss in solid organ transplant recipients.

Détails

ID Serval
serval:BIB_10C3CE32D79C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Clostridium difficile infection is associated with graft loss in solid organ transplant recipients.
Périodique
American journal of transplantation
Auteur(s)
Cusini A., Béguelin C., Stampf S., Boggian K., Garzoni C., Koller M., Manuel O., Meylan P., Mueller N.J., Hirsch H.H., Weisser M., Berger C., van Delden C.
Collaborateur(s)
Swiss Transplant Cohort Study
Contributeur(s)
Achermann R., Amico P., Aubert J.D., Banz V., Beldi G., Binet I., Bochud P.Y., Bucher H., Bühler L., Carell T., Catana E., Chalandon Y., de Geest S., de Rougemont O., Dickenmann M., Duchosal M., Elkrief L., Fehr T., Ferrari-Lacraz S., Gasche Soccal P., Gaudet C., Giostra E., Golshayan D., Hadaya K., Halter J., Heim D., Hess C., Hillinger S., Hofbauer G., Huynh-Do U., Immer F., Klaghofer R., Laesser B., Lehmann R., Lovis C., Marti H.P., Martin P.Y., Mohacsi P., Morel P., Mueller U., Mueller-McKenna H., Müller A., Müller T., Müllhaupt B., Nadal D., Pascual M., Passweg J., Rick J., Roosnek E., Rosselet A., Rothlin S., Ruschitzka F., Schanz U., Schaub S., Schnyder A., Seiler C., Steiger J., Stirnimann G., Toso C., Venetz J.P., Villard J., Wick M., Wilhelm M., Yerly P.
ISSN
1600-6143 (Electronic)
ISSN-L
1600-6135
Statut éditorial
Publié
Date de publication
07/2018
Peer-reviewed
Oui
Volume
18
Numéro
7
Pages
1745-1754
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Clostridium difficile infection (CDI) is a leading cause of infectious diarrhea in solid organ transplant recipients (SOT). We aimed to assess incidence, risk factors, and outcome of CDI within the Swiss Transplant Cohort Study (STCS). We performed a case-control study of SOT recipients in the STCS diagnosed with CDI between May 2008 and August 2013. We matched 2 control subjects per case by age at transplantation, sex, and transplanted organ. A multivariable analysis was performed using conditional logistic regression to identify risk factors and evaluate outcome of CDI. Two thousand one hundred fifty-eight SOT recipients, comprising 87 cases of CDI and 174 matched controls were included. The overall CDI rate per 10 000 patient days was 0.47 (95% confidence interval ([CI] 0.38-0.58), with the highest rate in lung (1.48, 95% CI 0.93-2.24). In multivariable analysis, proven infections (hazard ratio [HR] 2.82, 95% CI 1.29-6.19) and antibiotic treatments (HR 4.51, 95% CI 2.03-10.0) during the preceding 3 months were independently associated with the development of CDI. Despite mild clinical presentations, recipients acquiring CDI posttransplantation had an increased risk of graft loss (HR 2.24, 95% CI 1.15-4.37; P = .02). These findings may help to improve the management of SOT recipients.
Mots-clé
Anti-Bacterial Agents/therapeutic use, Case-Control Studies, Clostridium Infections/drug therapy, Clostridium Infections/epidemiology, Clostridium Infections/microbiology, Clostridium difficile/isolation & purification, Female, Follow-Up Studies, Graft Rejection/drug therapy, Graft Rejection/etiology, Graft Rejection/pathology, Graft Survival/drug effects, Humans, Incidence, Male, Middle Aged, Organ Transplantation/adverse effects, Postoperative Complications, Prognosis, Prospective Studies, Risk Factors, Switzerland/epidemiology, Transplant Recipients/statistics & numerical data, antibiotic: antibacterial, clinical research/practice, complication: infectious, infection and infectious agents - bacterial: Clostridium difficile, infectious disease
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2018 11:53
Dernière modification de la notice
16/12/2019 7:19
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