Right ventricular absolute myocardial blood flow in complex congenital heart disease.

Détails

ID Serval
serval:BIB_10AEC14C9480
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Right ventricular absolute myocardial blood flow in complex congenital heart disease.
Périodique
Heart (British Cardiac Society)
Auteur(s)
Rutz T., de Marchi S.F., Schwerzmann M., Vogel R., Seiler C.
ISSN
1468-201X (Electronic)
ISSN-L
1355-6037
Statut éditorial
Publié
Date de publication
07/2010
Peer-reviewed
Oui
Volume
96
Numéro
13
Pages
1056-1062
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
A consequence in patients with d-transposition of the great arteries (d-TGA) and tetralogy of Fallot (TOF) is right ventricular hypertrophy (RVH) and right ventricular failure. Myocardial contrast echocardiography (MCE) permits the determination of the myocardial microvascular density reflected by the relative myocardial blood volume (rBV; ml/ml). This study was conducted to elucidate the relationship between RVH and myocardial microvascular changes by quantitative MCE in patients with d-TGA and TOF.
Three groups of individuals were included in the study: 22 patients with d-TGA, 18 patients with TOF and 22 healthy individuals (controls). MCE was performed at rest and during adenosine-induced hyperaemia. rBV and myocardial blood flow (MBF; ml/min per gram) were derived from steady state and refill sequences of ultrasound contrast agent.
Hyperaemic septal rBV differed significantly between the groups and was highest in controls: d-TGA 0.141+/-0.060 ml/ml, TOF 0.134+/-0.080 ml/ml, controls 0.189+/-0.074 ml/ml, p=0.005. Myocardial blood flow reserve (MBFR), that is the ratio of hyperaemic to baseline MBF, differed significantly between the groups and was lowest in d-TGA (2.68+/-1.13) versus TOF (3.37+/-1.57) and controls (4.22+/-1.17, p=0.001). Hyperaemic septal rBV, MBF and MBFR showed a significant correlation with right ventricular systolic function as determined by tricuspid annular plane systolic excursion.
Right ventricular myocardial microvascular density of the septal wall in d-TGA and TOF patients with RVH due to pressure and/or volume overload is reduced. This appears to be related to a reduced myocardial perfusion reserve and impaired right ventricular systolic function.

Mots-clé
Adult, Coronary Circulation/physiology, Female, Heart Septal Defects, Ventricular/complications, Heart Septal Defects, Ventricular/diagnostic imaging, Heart Septal Defects, Ventricular/physiopathology, Humans, Hyperemia/complications, Hyperemia/diagnostic imaging, Hyperemia/physiopathology, Hypertrophy, Right Ventricular/complications, Hypertrophy, Right Ventricular/diagnostic imaging, Hypertrophy, Right Ventricular/physiopathology, Male, Microcirculation/physiology, Systole/physiology, Tetralogy of Fallot/complications, Tetralogy of Fallot/diagnostic imaging, Tetralogy of Fallot/physiopathology, Transposition of Great Vessels/complications, Transposition of Great Vessels/diagnostic imaging, Transposition of Great Vessels/physiopathology, Ultrasonography, Young Adult
Pubmed
Web of science
Création de la notice
07/08/2017 12:20
Dernière modification de la notice
20/08/2019 13:37
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