Regional heterogeneity in cardiac sympathetic innervation in acute myocardial infarction: relationship with myocardial oedema on magnetic resonance.

Détails

ID Serval
serval:BIB_10A7B9EE6756
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Regional heterogeneity in cardiac sympathetic innervation in acute myocardial infarction: relationship with myocardial oedema on magnetic resonance.
Périodique
European journal of nuclear medicine and molecular imaging
Auteur(s)
Gimelli A., Masci P.G., Liga R., Grigoratos C., Pasanisi E.M., Lombardi M., Marzullo P.
ISSN
1619-7089 (Electronic)
ISSN-L
1619-7070
Statut éditorial
Publié
Date de publication
09/2014
Peer-reviewed
Oui
Volume
41
Numéro
9
Pages
1692-1694
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
To assess the relationships between myocardial structure and function on cardiac magnetic resonance (CMR) imaging and sympathetic tone on (123)I-metaiodobenzylguanidine ((123)I-MIBG) scintigraphy early after myocardial infarction (MI).
Ten patients underwent (123)I-MIBG and (99m)Tc-tetrofosmin rest cadmium zinc telluride scintigraphy 4 ± 1 days after MI. The segmental left ventricular (LV) relative radiotracer uptake of both (99m)Tc-tetrofosmin and early (123)I-MIBG was calculated. The day after scintigraphy, on CMR imaging, the extent of ischaemia-related oedema and of myocardial fibrosis (late gadolinium enhancement, LGE) was assessed. Accordingly, the extent of oedema and LGE was evaluated for each segment and segmental wall thickening determined. Based on LGE distribution, LV segments were categorized as "infarcted" (56 segments), "adjacent" (66 segments) or "remote" (48 segments).
Infarcted segments showed a more depressed systolic wall thickening and greater extent of oedema than adjacent segments (p < 0.001) and remote segments (p < 0.001). Interestingly, while uptake of (99m)Tc-tetrofosmin was significantly depressed only in infarcted segments (p < 0.001 vs. both adjacent and remote segments), uptake of (123)I-MIBG was impaired not only in infarcted segments (p < 0.001 vs. remote) but also in adjacent segments (p = 0.024 vs. remote segments). At the regional level, after correction for (99m)Tc-tetrofosmin and LGE distribution, segmental (123)I-MIBG uptake (p < 0.001) remained an independent predictor of ischaemia-related oedema.
After acute MI the regional impairment of sympathetic tone extends beyond the area of altered myocardial perfusion and is associated with myocardial oedema.

Mots-clé
3-Iodobenzylguanidine, Acute Disease, Aged, Cadmium, Edema/complications, Female, Heart/innervation, Humans, Magnetic Resonance Imaging, Male, Myocardial Infarction/complications, Myocardial Infarction/diagnosis, Myocardial Infarction/diagnostic imaging, Myocardial Infarction/physiopathology, Radionuclide Imaging, Sympathetic Nervous System/diagnostic imaging, Sympathetic Nervous System/physiopathology, Tellurium, Zinc
Pubmed
Web of science
Création de la notice
25/08/2017 21:34
Dernière modification de la notice
20/08/2019 13:37
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