Risk and protective factors for recovery at 3-year follow-up after first-episode psychosis onset: a multivariate outcome approach.

Détails

Ressource 1Télécharger: Serra‑Arumí et al..pdf (870.25 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_10381AC26157
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Risk and protective factors for recovery at 3-year follow-up after first-episode psychosis onset: a multivariate outcome approach.
Périodique
Social psychiatry and psychiatric epidemiology
Auteur⸱e⸱s
Serra-Arumí C., Golay P., Bonnarel V., Alerci L., Abrahamyan Empson L., Conus P., Alameda L.
ISSN
1433-9285 (Electronic)
ISSN-L
0933-7954
Statut éditorial
Publié
Date de publication
07/2024
Peer-reviewed
Oui
Volume
59
Numéro
7
Pages
1255-1267
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Recovery in people with first-episode psychosis (FEP) remains a major issue. When risk factors are studied in relation to the disorder, potential protective factors should also be considered since they can modulate this relationship. This study is aimed at exploring which premorbid and baseline characteristics are associated with a good and poor global recovery in patients with FEP at 3-year follow-up.
We categorized patients' outcome by using a Latent Class Analysis (LCA) considering a multimodal set of symptomatic and functional outcomes. A Mixed effects Models Repeated Measures analysis of variance (MMRM) was used to highlight group differences over time on symptomatic and functional outcomes assessed during the 3-year follow-up.
A total of 325 patients with FEP aged between 18 and 35 years were included. Two groups were identified. A total of 187 patients (57.5%) did not achieve recovery, and 138 patients (42.5%) achieved recovery. Recovered patients had generally a better premorbid and baseline profile in comparison with non-recovered patients (as among which shorter duration of untreated psychosis (DUP), higher degree of insight, better functional level and lower illness severity at baseline). The trajectories for the psychopathological and functional outcomes over 36 months differed between the non-recovered and the recovered group of patients.
Our results pointed to some variables associated with recovery, acting as potential protective factors. These should be considered for early intervention programs to promote psychological resilience specifically in those with a worse prognosis in order to mitigate the effects of the variables that make them more vulnerable to poorer outcome.
Mots-clé
Humans, Psychotic Disorders/psychology, Female, Male, Adult, Follow-Up Studies, Risk Factors, Young Adult, Protective Factors, Adolescent, Latent Class Analysis, Psychiatric Status Rating Scales, Early intervention, Early psychosis, Outcome, Protective factors, Recovery
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/10/2023 10:42
Dernière modification de la notice
22/06/2024 7:07
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