Hemophilie acquise. A propos d'une observation avec evolution fatale. [Acquired hemophilia. Apropos of a case report with a fatal course]

Détails

ID Serval
serval:BIB_1007BBE29B2B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Hemophilie acquise. A propos d'une observation avec evolution fatale. [Acquired hemophilia. Apropos of a case report with a fatal course]
Périodique
Schweizerische Medizinische Wochenschrift
Auteur(s)
de Moerloose  P., Tissot  J. D., Reber  G., Schifferli  J., Vogel  J., Bouvier  C. A.
ISSN
0036-7672 (Print)
Statut éditorial
Publié
Date de publication
10/1988
Volume
118
Numéro
42
Pages
1542-5
Notes
Case Reports
English Abstract
Journal Article --- Old month value: Oct 22
Résumé
We report the case of an 86-year-old female with an unremarkable past history who suddenly developed severe and generalized bleeding. Laboratory work-up revealed prolonged aPTT, a factor VIII level of 7% and the presence of a factor VIII inhibitor. In spite of whole blood, factor VIII concentrates and immunoglobulin administration, the patient died of multiple hemorrhages on the third day after admission. At autopsy no causal or associated pathology could be found. Chromatographic separation of plasma immunoglobulins showed that the anti-factor VIII activity was associated with the patient's IgG. This inhibition was partially corrected in vitro by injectable immunoglobulin preparation. The case report stresses the discrepancy between the measured levels of inhibitor and the severity of the bleeding; our in vitro results may shed light on the mode of action of intravenous immunoglobulins.
Mots-clé
Aged Blood Transfusion Factor VIII/*analogs & derivatives/analysis/therapeutic use Female Hemophilia A/*blood/complications/therapy Hemorrhage/etiology Humans Immunization, Passive/methods Immunoglobulin G
Pubmed
Web of science
Création de la notice
25/01/2008 16:34
Dernière modification de la notice
20/08/2019 13:36
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