Post-translational modifications regulate distinct functions of CARMA1 and BCL10.

Détails

ID Serval
serval:BIB_0FFC473E6ECC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Post-translational modifications regulate distinct functions of CARMA1 and BCL10.
Périodique
Trends in Immunology
Auteur(s)
Thome M., Weil R.
ISSN
1471-4906[print], 1471-4906[linking]
Statut éditorial
Publié
Date de publication
2007
Volume
28
Numéro
6
Pages
281-288
Langue
anglais
Résumé
Activation of the transcription factor nuclear factor (NF)-kappaB is essential for the normal functioning of the immune system. Deregulated NF-kappaB signalling in lymphocytes can lead to immunodeficiency, but also to autoimmunity or lymphomas. Many of the signalling components controlling NF-kappaB activation in lymphocytes are now known, but it is less clear how distinct molecular components of this pathway are regulated. Here, we summarize recent findings on post-translational modifications of intracellular components of this pathway. Phosphorylation of the CARMA1 and BCL10 proteins and ubiquitylation of BCL10 affect the formation and stability of the CARMA1-BCL10-MALT1 (CBM) complex, and also control negative feedback regulation of the NF-kappaB signalling pathway. Moreover, the study of BCL10 phosphorylation isoforms has revealed a new mechanism controlling BCL10 nuclear translocation and an unexpected role for BCL10 in the regulation of the actin cytoskeleton.
Mots-clé
Actins/chemistry, Active Transport, Cell Nucleus, Adaptor Proteins, Signal Transducing/physiology, Animals, Apoptosis Regulatory Proteins/physiology, CARD Signaling Adaptor Proteins/physiology, Guanylate Cyclase/physiology, Humans, NF-kappa B/metabolism, Phosphorylation, Protein Kinase C/physiology, Protein Processing, Post-Translational, Ubiquitin/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 16:11
Dernière modification de la notice
20/08/2019 13:36
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