Effect of apolipoprotein E alleles and angiotensin-converting enzyme insertion/deletion polymorphisms on lipid and lipoprotein markers in middle-aged men and in patients with stable angina pectoris or healed myocardial infarction

Détails

ID Serval
serval:BIB_0FF961BCBE15
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of apolipoprotein E alleles and angiotensin-converting enzyme insertion/deletion polymorphisms on lipid and lipoprotein markers in middle-aged men and in patients with stable angina pectoris or healed myocardial infarction
Périodique
American Journal of Cardiology
Auteur(s)
Marques-Vidal P., Bongard V., Ruidavets J.B., Fauvel J., Perret B., Ferrières J.
ISSN
0002-9149 (Print)
ISSN-L
0002-9149
Statut éditorial
Publié
Date de publication
2003
Volume
92
Numéro
9
Pages
1102-1105
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The effects of the apolipoprotein E epsilon and angiotensin-converting enzyme insertion/deletion alleles on lipid levels and hypolipidemic drug treatment was assessed in 400 men with stable angina pectoris or healed myocardial infarction and 338 healthy controls. The data indicate that epsilon4 carriers have increased total and low-density lipoprotein cholesterol levels, that the epsilon4 allele unfavorably decreases the efficiency of statin treatment, and that the angiotensin-converting enzyme insertion/deletion polymorphism exerts no significant effect, with the exception of an increase in apolipoprotein E levels.
Mots-clé
Angina Pectoris/blood, Angina Pectoris/genetics, Angina Pectoris/therapy, Apolipoproteins E/genetics, Hyperlipidemias/blood, Hyperlipidemias/genetics, Hyperlipidemias/therapy, Lipoproteins/blood, Myocardial Infarction/blood, Myocardial Infarction/genetics, Myocardial Infarction/therapy, Peptidyl-Dipeptidase A/genetics, Polymorphism, Genetic/genetics
Pubmed
Web of science
Création de la notice
01/12/2016 15:01
Dernière modification de la notice
20/08/2019 12:36
Données d'usage