Two-year outcome of an observe-and-plan regimen for neovascular age-related macular degeneration: how to alleviate the clinical burden with maintained functional results.

Détails

ID Serval
serval:BIB_0FECC5CD4C9A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Two-year outcome of an observe-and-plan regimen for neovascular age-related macular degeneration: how to alleviate the clinical burden with maintained functional results.
Périodique
Eye (london, England)
Auteur(s)
Gianniou C., Dirani A., Ferrini W., Marchionno L., Decugis D., Deli A., Ambresin A., Mantel I.
ISSN
1476-5454 (Electronic)
ISSN-L
0950-222X
Statut éditorial
Publié
Date de publication
2015
Volume
29
Numéro
3
Pages
342-349
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
PurposeThe purpose of this study was to report the 2-year outcome of an individually tailored 'observe-and-plan' treatment regimen for neovascular age-related macular degeneration (nAMD), and to investigate its clinical value in terms of functional outcome. This regimen aimed to reduce the clinical burden (visits) by employing individually fixed injection intervals, based on the predictability of an individual's need for retreatment.MethodsThis prospective case series included 104 patients (115 eyes) with nAMD. Following three loading doses of ranibizumab, the disease recurrence interval was determined in monthly observation visits. Retreatment was applied in a series of three injections with individually fixed intervals (2 weeks shorter than the recurrence interval), combined with periodic adjustment of the intervals. The allowed injection intervals in treatment plans ranged from 1 to 3 months. If there was no recurrence at 3 months, the patient could change to monitoring alone.ResultsMean visual acuity (VA) improved by 8.7, 9.7, and 9.2 letters at months 3, 12, and 24, respectively. The mean number of injections was 7.8 and 5.8 during years 1 and 2, respectively, whereas the mean number of ophthalmic examinations was 4.0 and 2.9, respectively. The mean treatment interval (after the loading doses) was 2.0 months during year 1, and 2.2 months during year 2.ConclusionThe observe-and-plan regimen significantly improved and maintained VA over the course of 2 years. This favourable functional outcome was achieved with fewer clinic visits compared with other regimens. Therefore, this observe-and-plan regimen has the potential to alleviate the clinical burden of nAMD treatment.
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/04/2015 13:37
Dernière modification de la notice
20/08/2019 13:36
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