Growth and Puberty in Juvenile Dermatomyositis: A Longitudinal Cohort Study.

Détails

ID Serval
serval:BIB_0FEB30EB7BA1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Growth and Puberty in Juvenile Dermatomyositis: A Longitudinal Cohort Study.
Périodique
Arthritis care & research
Auteur(s)
Nordal E., Pistorio A., Rygg M., Giancane G., Maghnie M., Di Iorgi N., Flemming K., Hofer M., Melo-Gomes J.A., Bica BERG, Brunner J., Dannecker G., Gerloni V., Harjacek M., Huppertz H.I., Pratsidou-Gertsi P., Nielsen S., Stanevicha V., Ten Cate R., Vougiouka O., Pastore S., Simonini G., Ravelli A., Martini A., Ruperto N.
Collaborateur(s)
Paediatric Rheumatology International Trials Organisation
ISSN
2151-4658 (Electronic)
ISSN-L
2151-464X
Statut éditorial
Publié
Date de publication
02/2020
Peer-reviewed
Oui
Volume
72
Numéro
2
Pages
265-273
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
To study growth and puberty in a multinational longitudinal prospective cohort of children with juvenile dermatomyositis (DM).
Children from 31 countries who were ages <18 years and had juvenile DM in active phase were studied, and analyses of height, weight, and pubertal development were conducted in those who had follow-up visits during a 2-year period and for whom anthropometric data was available.
A total of 196 of 275 children (71%) were included. We found a significant reduction in parent-adjusted height Z score over time in female patients (P < 0.0001) and male patients (P = 0.001), but with catch-up growth at the final study visit. Median body mass index Z score peaked at 6 months (P < 0.0001) and was still significantly above baseline at the final study visit, which was at a median of 26 months after baseline (P = 0.007), with no difference between sexes. Female patients with a disease duration ≥12 months after onset had significantly lower parent-adjusted height Z score (P = 0.002) and no 2-year catch-up growth. At the final study visit, growth failure was seen in 20 of 97 female patients (21%) and in 11 of 73 male patients (15%). Height deflection (∆height Z score less than -0.25/year) was observed in 29 of 116 female patients (25%) and 25 of 80 male patients (31.3%). Delayed puberty was seen in 20 of 55 female patients (36.4%) and in 11 of 31 male patients (35.5%). Children in early pubertal stage at baseline had the highest risk of growth failure.
Juvenile DM in the active phase and/or its treatment has a significant impact on growth and puberty in affected children. Children with recent onset of puberty or previous growth failure have the highest risk of delayed pubertal development and further growth retardation.
Mots-clé
Adolescent, Child, Child, Preschool, Cohort Studies, Dermatomyositis/diagnosis, Dermatomyositis/physiopathology, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Puberty/physiology
Pubmed
Création de la notice
13/09/2019 11:16
Dernière modification de la notice
22/02/2020 7:26
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