Cytomegalovirus fetal infection: prenatal diagnosis

Détails

ID Serval
serval:BIB_0FE21FBD85F1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cytomegalovirus fetal infection: prenatal diagnosis
Périodique
Obstetrics and Gynecology
Auteur(s)
Hohlfeld  P., Vial  Y., Maillard-Brignon  C., Vaudaux  B., Fawer  C. L.
ISSN
0029-7844 (Print)
Statut éditorial
Publié
Date de publication
10/1991
Volume
78
Numéro
4
Pages
615-8
Notes
Journal Article --- Old month value: Oct
Résumé
We report the results of prenatal diagnosis in 15 cases of primary cytomegalovirus infection during pregnancy. Sixteen fetuses (one twin pregnancy) were examined by ultrasonography, amniocentesis, and fetal blood sampling. Prenatal diagnosis was positive in eight cases as evidenced by positive amniotic fluid cultures in eight, positive immunoglobulin M (IgM) in six, and abnormal ultrasound in two. Among infected fetuses, abnormal laboratory findings included anemia, thrombocytopenia, and elevated liver function tests. Three pregnancies were terminated because of ultrasound abnormality or abnormal laboratory indices. In cases of fetal infection with normal ultrasound and normal laboratory findings, the pregnancies were allowed to proceed, leading to the birth of four infants (three with subclinical infections, one with bilateral hearing loss). The relation between anemia, thrombocytopenia, altered liver function tests, and subsequent handicap remains unknown, but the abnormalities observed in utero correspond to those described at birth in cases of cytomegalic inclusion disease. Amniocentesis alone allowed the diagnosis of infection in all cases, but fetal blood sampling provided additional information about the fetal condition.
Mots-clé
Cytomegalovirus Infections/*diagnosis Female Fetal Diseases/*diagnosis Humans Pregnancy *Pregnancy Complications, Infectious *Prenatal Diagnosis/methods
Pubmed
Web of science
Création de la notice
25/01/2008 11:11
Dernière modification de la notice
20/08/2019 12:36
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