Prospective risk of morbidity in relation to malaria infection in an area of high endemicity of multiple species of Plasmodium

Détails

ID Serval
serval:BIB_0FE06D18C6BF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Prospective risk of morbidity in relation to malaria infection in an area of high endemicity of multiple species of Plasmodium
Périodique
American Journal of Tropical Medicine and Hygiène
Auteur(s)
Smith  T., Genton  B., Baea  K., Gibson  N., Narara  A., Alpers  M. P.
ISSN
0002-9637 (Print)
Statut éditorial
Publié
Date de publication
06/2001
Volume
64
Numéro
5-6
Pages
262-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May-Jun
Résumé
In an area of Papua New Guinea with high prevalence of Plasmodium falciparum (39.6%), Plasmodium vivax (18.3%), and Plasmodium malariae (13.8%), cross-sectional analysis found P. falciparum infection to be independent of the other species despite heterogeneities in transmission. Plasmodium vivax and P. malariae infections were negatively correlated. Plasmodium malariae infection was positively associated with homologous infection four months previously and with prior P. falciparum, but not P. vivax infection. There were no other indications that any Plasmodium species protected against heterologous infection. Prospective analysis of health-center morbidity supported the idea that P. malariae infection protects against disease, but indicated greater protection against non-malaria than P. falciparum-associated fevers. Plasmodium vivax appeared to protect against P. falciparum disease but not against other forms of morbidity. Covariate adjustment had considerable effects on estimated relationships between species, and confounding variables may account for many differences among reports of inter-species interactions in human malaria.
Mots-clé
Animals Cross-Sectional Studies Humans Malaria/epidemiology/parasitology/*physiopathology Morbidity New Guinea/epidemiology Plasmodium/classification/*isolation & purification Prospective Studies Risk Factors Species Specificity
Pubmed
Web of science
Création de la notice
28/01/2008 12:48
Dernière modification de la notice
20/08/2019 13:36
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